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General Information
Symbol
TNT-LC
FlyBase ID
FBto0000575
Name
tetanus toxin light chain
Description
Description

TNT-LC corresponds to the light chain encoded by the Clostridium tetani tetanus toxin (tetX) gene (UniProtKB:P04958). TNT-LC can be used as a tool to inhibit neuron activity; the toxin selectively cleaves presynaptic VAMP2 (nSyb in Drosophila), preventing synaptic vesicle exocytosis and abolishing synaptic transmission (PMID:12890769, FBrf0080431).

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Transgenic Constructs
Insertions ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
TNT-LC
Name Synonyms
tetanus toxin light chain
Secondary FlyBase IDs
    References (11)