deGradHA is an engineered F-box protein that targets Tag:HA-tagged proteins for degradation via the ubiquitin pathway. deGradHA contains the N-terminal 198 amino acids of D. melanogaster slmb (this includes the F-box domain), fused to scFv(antiHA-X15F11), an engineered single-chain variable fragment antibody that binds the Tag:HA epitope. Upon expression of deGradHA, target proteins tagged with Tag:HA are specifically polyubiquitinated and rapidly degraded by the proteasome (FBrf0248474).