Recombinant construct P{UAS-kuz.F}

General Information
Symbol	P{UAS-kuz.F}	FlyBase ID	FBtp0007245
Feature type	transgenic_transposon

Size		Expression data
Associated insertions	1 available
Molecular map
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Description & Uses
Species	synthetic construct
Location-dependent role
Description	CV term Qualifiers & info Reference transposon P-element (Fambrough et al., 1996)
Uses	CV term Qualifiers & info Reference binary system (targeted) kuz (Fambrough et al., 1996) characterization kuz (Fambrough et al., 1996)
Cloning Sites	Location Restriction sites Reference
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Extent
Segments & Size
Total Size
Left end
Right end

Segments	Number Orientation Symbol
Reference
Features
	CV term Qualifiers & info Reference binary component (Fambrough et al., 1996)
Component Alleles
Allele	kuz^Scer\UAS.cFa
Reference(s)	(Fambrough et al., 1996, Sotillos et al., 1997, Sapir et al., 2005, Meyer and Aberle, 2006, Wang et al., 2007, Wentzell et al., 2012, Carmine-Simmen et al., 2009, Wang et al., 2006)
Molecular data	Construct: A 4.9kb kuz cDNA fragment, containing the entire coding region, is expressed under the control of Scer\UAS regulatory sequences. (Fambrough et al., 1996)
Phenotypic class
Phenotype manifest in
Other information

Allele	w^+mC
Reference(s)	(Fambrough et al., 1996)
Molecular data	Minigene of the white cDNA. (Chung et al., 1993) 4.15kb SpeI fragment of the w gene that carries a deletion of a large part of the first intron and the regulatory region is reduced to 300bp preceding the transcription start site. (Pirrotta, 1988) Construct: A 'mini-white' gene constructed by deletion of the HindIII-XbaI fragment from the long 5' intron. Carried by the Casper series of vectors.
Phenotypic class	courtship behavior defective \| male (Lloyd et al., 2002, Hing and Carlson, 1996) eye color defective (Soldatov et al., 1999, Hagstrom et al., 1996) eye color defective, with Scer\GAL4^Act5C.PI, w^{dsRNA.Sym.Scer\UAS} (Giordano et al., 2002) visible \| dominant (True et al., 1996) visible \| recessive (Roseman et al., 1993)
Phenotype manifest in	pigment cell (Soldatov et al., 1999, Hagstrom et al., 1996, Roseman et al., 1993, Dorer and Henikoff, 1994, Qian and Pirrotta, 1995) pigment cell, with Scer\GAL4^Act5C.PI, w^{dsRNA.Sym.Scer\UAS} (Giordano et al., 2002)
Other information
Expression Data
Reporter Expression

Additional Information
Statement Reference

Marker for
Reflects expression of
Progenitors & Descendants
progenitor(s)
descendant(s)
Comments

Stocks Listed in FlyBase ( 2 )
Bloomington	5816 w^*; P{UAS-kuz.F}DF1
Kyoto	108440 w^*; P{UAS-kuz.F}DF1
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs
Reported As
Symbol Synonym	P{UAS-kuz.F} (FlyBase, 1996-) UAS-kuz (Sapir et al., 2005, Carmine-Simmen et al., 2009, Wentzell et al., 2012) UAS-kuz^F (Meyer and Aberle, 2006) UAS-KUZ-F (Wang et al., 2006, Wang et al., 2007)
Secondary FlyBase IDs

References ( 8 )
Research paper	Wentzell et al., 2012, Neurobiol. Disease 46(1): 78--87 Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration. [FBrf0217742] Carmine-Simmen et al., 2009, Neurobiol. Disease 33(2): 274--281 Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function. [FBrf0206813] Wang et al., 2007, Dev. Biol. 301(2): 532--540 Spatially localized Kuzbanian required for specific activation of Notch during border cell migration. [FBrf0191839] Meyer and Aberle, 2006, Development 133(20): 4035--4044 At the next stop sign turn right: the metalloprotease Tolloid-related 1 controls defasciculation of motor axons in Drosophila. [FBrf0193012] Wang et al., 2006, Dev. Cell 10(4): 483--495 Analysis of cell migration using whole-genome expression profiling of migratory cells in the Drosophila ovary. [FBrf0190227] Sapir et al., 2005, Development 132(1): 123--132 Unidirectional Notch signaling depends on continuous cleavage of Delta. [FBrf0188426] Sotillos et al., 1997, Development 124(23): 4769--4779 The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs. [FBrf0099884] Fambrough et al., 1996, Proc. Natl. Acad. Sci. U.S.A. 93(23): 13233--13238 The cell surface metalloprotease/disintegrin Kuzbanian is required for axonal extension in Drosophila. [FBrf0090545]