Recombinant construct P{GMR-HTT.Q120}

General Information
Symbol	P{GMR-HTT.Q120}	FlyBase ID	FBtp0010067
Feature type	transgenic_transposon

Size		Expression data
Associated insertions	2 available
Molecular map
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Description & Uses
Species	synthetic construct
Location-dependent role
Description	CV term Qualifiers & info Reference transposon P-element (Jackson et al., 1998)
Uses	CV term Qualifiers & info Reference characterization GMR (Jackson et al., 1998)
Cloning Sites	Location Restriction sites Reference
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Extent
Segments & Size
Total Size
Left end
Right end

Segments	Number Orientation Symbol
Reference
Features
	CV term Qualifiers & info Reference
Component Alleles
Allele	Hsap\HTT^GMR.Q120
Reference(s)	(Jackson et al., 1998, Kanuka et al., 2003, Ravikumar et al., 2004, Boeddrich et al., 2006, Warrick et al., 2005, Hoshino et al., 2006, Berger et al., 2006, Tamura et al., 2011, Venkatachalam et al., 2008, Rusten et al., 2007, Kazemi-Esfarjani and Benzer, 2002, Wang et al., 2009, Berger et al., 2005, Chan et al., 2000)
Molecular data	Construct: Expression of Hsap\HD amino acids 1-170, with 120 CAG glutamine repeats is governed by the GMR promoter. (Jackson et al., 1998)
Phenotypic class	increased cell death (Wang et al., 2009) neuroanatomy defective (Kanuka et al., 2003, Tamura et al., 2011) neuroanatomy defective \| progressive (Chan et al., 2000) visible \| dominant (Jackson et al., 1998)
Phenotype manifest in	eye (Kanuka et al., 2003, Kazemi-Esfarjani and Benzer, 2002) eye, with Scer\GAL4^GMR.long (Hoshino et al., 2006) eye photoreceptor cell (Boeddrich et al., 2006, Venkatachalam et al., 2008, Rusten et al., 2007, Tamura et al., 2011) eye photoreceptor cell, with Scer\GAL4^GMR.long (Hoshino et al., 2006) ommatidium (Jackson et al., 1998, Ravikumar et al., 2004) ommatidium, with Scer\GAL4^GMR.long (Hoshino et al., 2006) photoreceptor cell (Wang et al., 2009) retina (Warrick et al., 2005) retina \| progressive (Chan et al., 2000) rhabdomere (Jackson et al., 1998, Ravikumar et al., 2004, Wang et al., 2009) rhabdomere \| adult stage (Berger et al., 2006) rhabdomere \| conditional (Berger et al., 2005)
Other information
Expression Data
Reporter Expression

Additional Information
Statement Reference

Marker for
Reflects expression of
Progenitors & Descendants
progenitor(s)
descendant(s)
Comments

Stocks Listed in FlyBase ( 2 )
Bloomington	8533 y¹ w¹¹¹⁸; P{GMR-HTT.Q120}2.4 8534 w¹¹¹⁸; wg^Sp-1/CyO; P{GMR-HTT.Q120}4.62/TM6B, Tb¹
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs
Reported As
Symbol Synonym	120Q (Berger et al., 2006) Gln¹²⁰ (Ravikumar et al., 2004) gmr-HDQ120 (Venkatachalam et al., 2008) GMR-Htt120Q (Hoshino et al., 2006) GMR-htt.Q120 (Wang et al., 2009) gmr-Htt-Q120 (Warrick et al., 2005) gmr-HttQ120 (Boeddrich et al., 2006) gmr-htt-Q120 (Chan et al., 2000) Gmr-HttQ120 (Rusten et al., 2007) gmr-httQ120 (Berger et al., 2005) GMR-huntingtin120Q (Kanuka et al., 2003) GMR-Huntingtin^120Q (Tamura et al., 2011) gmr-Q120 (Berger et al., 2006) HttQ120 (Kazemi-Esfarjani and Benzer, 2002) P{GMR-HD.Q120} (FlyBase, 1996-) P{GMR-HTT.Q120} (FlyBase, 1996-) Q120 (Berger et al., 2006)
Secondary FlyBase IDs

References ( 15 )
Research paper	Tamura et al., 2011, PLoS ONE 6(11): e27408 Ku70 Alleviates Neurodegeneration in Drosophila Models of Huntington's Disease. [FBrf0216723] Wang et al., 2009, J. Cell Biol. 186(5): 703--711 TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease. [FBrf0208794] Venkatachalam et al., 2008, Cell 135(5): 838--851 Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells. [FBrf0206372] Rusten et al., 2007, Curr. Biol. 17(20): 1817--1825 ESCRTs and Fab1 regulate distinct steps of autophagy. [FBrf0201360] Berger et al., 2006, Hum. Mol. Genet. 15(3): 453--465 Deleterious and protective properties of an aggregate-prone protein with a polyalanine expansion. [FBrf0190826] Boeddrich et al., 2006, EMBO J. 25(7): 1547--1558 An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis. [FBrf0190355] Hoshino et al., 2006, J. Cell Biol. 172(4): 589--604 Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73. [FBrf0190936] Berger et al., 2005, Hum. Mol. Genet. 14(20): 3003--3011 Lithium rescues toxicity of aggregate-prone proteins in Drosophila by perturbing Wnt pathway. [FBrf0190825] Warrick et al., 2005, Mol. Cell 18(1): 37--48 Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism. [FBrf0188095] Ravikumar et al., 2004, Nat. Genet. 36(6): 585--595 Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. [FBrf0179401] Kanuka et al., 2003, Proc. Natl. Acad. Sci. U.S.A. 100(20): 11723--11728 Cytosol-endoplasmic reticulum interplay by Sec61α translocon in polyglutamine-mediated neurotoxicity in Drosophila. [FBrf0173066] Kazemi-Esfarjani and Benzer, 2002, Hum. Mol. Genet. 11(21): 2657--2672 Suppression of polyglutamine toxicity by a Drosophila homolog of myeloid leukemia factor 1. [FBrf0152072] Chan et al., 2000, Hum. Mol. Genet. 9(19): 2811--2820 Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila. [FBrf0131269] Jackson et al., 1998, Neuron 21(3): 633--642 Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons. [FBrf0104757]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]