Recombinant construct P{UAS-Pten.Gb}

General Information
Symbol	P{UAS-Pten.Gb}	FlyBase ID	FBtp0012872
Feature type	transgenic_transposon

Size		Expression data
Associated insertions	0 available
Molecular map
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Description & Uses
Species	synthetic construct
Location-dependent role
Description	CV term Qualifiers & info Reference transposon P-element (Gao et al., 2000)
Uses	CV term Qualifiers & info Reference binary system (targeted) Pten (Gao et al., 2000) characterization Pten (Gao et al., 2000)
Cloning Sites	Location Restriction sites Reference
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Extent
Segments & Size
Total Size
Left end
Right end

Segments	Number Orientation Symbol
Reference
Features
	CV term Qualifiers & info Reference binary component (Gao et al., 2000)
Component Alleles
Allele	Pten^Scer\UAS.cGb
Reference(s)	(Mirth et al., 2005, Stocker et al., 2003, Saucedo et al., 2003, Takeo et al., 2005, Britton et al., 2002, Wu et al., 2005, Szuplewski et al., 2003, Hwangbo et al., 2004, Juhász et al., 2007, Gao et al., 2000, Scott et al., 2004, Rusten et al., 2004, Tapon et al., 2001, Mikeladze-Dvali et al., 2005, Mirth et al., 2009, Ford et al., 2007, Wang et al., 2009, Haberman et al., 2010, Eddison et al., 2011)
Molecular data
Phenotypic class	aging defective, with Scer\GAL4^Scer\UAS.cHa, Scer\GAL4^tin.cBa (Wessells et al., 2004) chemical resistant, with Scer\GAL4^elav-C155 (Eddison et al., 2011) chemical resistant \| adult stage \| heat sensitive, with Scer\GAL4^elav-C155, Scer\GAL80^ts.αTub84B (Eddison et al., 2011) decreased cell number, with Scer\GAL4^ap-md544 (Gao et al., 2000) decreased cell number, with Scer\GAL4^Bx-MS1096 (Gao et al., 2000) decreased cell number, with Scer\GAL4^en-e16E (Gao et al., 2000) decreased cell size, with Scer\GAL4^ap-md544 (Gao et al., 2000) decreased cell size, with Scer\GAL4^Bx-MS1096 (Gao et al., 2000) decreased cell size, with Scer\GAL4^en-e16E (Gao et al., 2000) decreased cell size \| somatic clone, with Scer\GAL4^Act5C.PP (Britton et al., 2002) developmental rate defective \| second instar larval stage, with Scer\GAL4^P0206 (Mirth et al., 2005) developmental rate defective \| third instar larval stage, with Scer\GAL4^P0206 (Mirth et al., 2005) large body \| pharate adult stage, with Scer\GAL4^P0206 (Mirth et al., 2005) large body \| second instar larval stage, with Scer\GAL4^P0206 (Mirth et al., 2005) lethal, with Scer\GAL4^arm.PS (Gao et al., 2000) lethal \| first instar larval stage, with Scer\GAL4^phm.PO (Mirth et al., 2005) lethal \| partially \| pupal stage, with Scer\GAL4^P0206 (Mirth et al., 2005) long lived \| RU486 conditional, with Scer\GAL4^{bun-Switch1.32} (Hwangbo et al., 2004) short lived \| RU486 conditional, with Scer\GAL4^{elav.Switch.PO} (Ford et al., 2007) small body, with Scer\GAL4^arm.PS (Gao et al., 2000) viable, with Scer\GAL4^Scer\UAS.cHa, Scer\GAL4^tin.cBa (Wessells et al., 2004) visible, with Scer\GAL4^ey.PH (Tapon et al., 2001) wild-type \| RU486 conditional, with Scer\GAL4^Switch1.106 (Hwangbo et al., 2004)
Phenotype manifest in	adult heart, with Scer\GAL4^Scer\UAS.cHa, Scer\GAL4^tin.cBa (Wessells et al., 2004) embryonic/larval corpus allatum, with Scer\GAL4^P0206 (Mirth et al., 2005) embryonic/larval fat body \| somatic clone, with Scer\GAL4^Act5C.PP (Britton et al., 2002) embryonic/larval salivary gland, with Scer\GAL4^29BD (Takeo et al., 2005) embryonic/larval salivary gland \| somatic clone, with Scer\GAL4^Act5C.PP (Britton et al., 2002) eye, with Scer\GAL4^ey.PH (Tapon et al., 2001) eye, with Scer\GAL4^GMR.PF (Saucedo et al., 2003) fat body, with Scer\GAL4^Lsp2.PH (Haberman et al., 2010) ommatidium, with Scer\GAL4^GMR.PF (Stocker et al., 2003) prothoracic gland, with Scer\GAL4^P0206 (Mirth et al., 2005) puparium, with Scer\GAL4^P0206 (Mirth et al., 2005) wing, with Scer\GAL4^Bx-MS1096 (Gao et al., 2000) wing, with Scer\GAL4^P0206 (Mirth et al., 2005) wing \| dorsal compartment, with Scer\GAL4^ap-md544 (Gao et al., 2000) wing \| posterior compartment, with Scer\GAL4^en-e16E (Gao et al., 2000)
Other information
Expression Data
Reporter Expression

Additional Information
Statement Reference

Marker for
Reflects expression of
Progenitors & Descendants
progenitor(s)
descendant(s)
Comments

Stocks Listed in FlyBase ( 0 )

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs
Reported As
Symbol Synonym	P{UAS-Pten.Gb} (FlyBase, 1996-, Ford et al., 2007) UAS-dPTEN (Wu et al., 2005, Rusten et al., 2004, Hwangbo et al., 2004, Szuplewski et al., 2003, Britton et al., 2002, Tapon et al., 2001, Gao et al., 2000) UAS-Pten (Takeo et al., 2005, Haberman et al., 2010, Eddison et al., 2011) UAS-PTEN (Scott et al., 2004, Saucedo et al., 2003, Stocker et al., 2003) UAS Pten (Mirth et al., 2009) UASPTEN (Juhász et al., 2007) UAS-pten (Wang et al., 2009) UAS-TSC2 (Mikeladze-Dvali et al., 2005)
Secondary FlyBase IDs

References ( 19 )
Research paper	Eddison et al., 2011, Neuron 70(5): 979--990 arouser Reveals a Role for Synapse Number in the Regulation of Ethanol Sensitivity. [FBrf0213908] Haberman et al., 2010, Development 137(13): 2157--2166 Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking. [FBrf0211007] Mirth et al., 2009, Development 136(14): 2345--2353 The Ecdysone receptor controls the post-critical weight switch to nutrition-independent differentiation in Drosophila wing imaginal discs. [FBrf0208188] Wang et al., 2009, J. Cell Biol. 186(5): 703--711 TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease. [FBrf0208794] Ford et al., 2007, Exp. Gerontol. 42(6): 483--497 Alteration of Drosophila life span using conditional, tissue-specific expression of transgenes triggered by doxycyline or RU486/Mifepristone. [FBrf0200753] Juhász et al., 2007, Cell Death Differ. 14(6): 1181--1190 Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. [FBrf0194904] Mikeladze-Dvali et al., 2005, Cell 122(5): 775--787 The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors. [FBrf0187233] Mirth et al., 2005, Curr. Biol. 15(20): 1796--1807 The role of the prothoracic gland in determining critical weight for metamorphosis in Drosophila melanogaster. [FBrf0190035] Takeo et al., 2005, Dev. Biol. 284(1): 204--218 Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog. [FBrf0187400] Wu et al., 2005, Proc. Natl. Acad. Sci. U.S.A. 102(37): 13289--13294 Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila. [FBrf0188283] Hwangbo et al., 2004, Nature 429(6991): 562--566 Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. [FBrf0179031] Rusten et al., 2004, Dev. Cell 7(2): 179--192 Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. [FBrf0180118] Saucedo et al., 2003, Nat. Cell Biol. 5(6): 566--571 Rheb promotes cell growth as a component of the insulin/TOR signalling network. [FBrf0160913] Szuplewski et al., 2003, Development 130(16): 3651--3662 The Drosophila bZIP transcription factor Vrille is involved in hair and cell growth. [FBrf0160992] Britton et al., 2002, Dev. Cell 2(2): 239--249 Drosophila's Insulin/PI3-Kinase pathway coordinates cellular metabolism with nutritional conditions. [FBrf0144797] Tapon et al., 2001, Cell 105(3): 345--355 The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. [FBrf0135684] Gao et al., 2000, Dev. Biol. 221(2): 404--418 Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways. [FBrf0127089]
Supplementary material	Scott et al., 2004, Dev. Cell 7(2): Supplementary material. [FBrf0183440]
Letter	Stocker et al., 2003, Nat. Cell Biol. 5(6): 559--565 Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. [FBrf0160980]