Recombinant construct P{UAS-Fmr1.Z}

General Information
Symbol	P{UAS-Fmr1.Z}	FlyBase ID	FBtp0015411
Feature type	transgenic_transposon

Size		Expression data
Associated insertions	1 available
Molecular map
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Description & Uses
Species	synthetic construct
Location-dependent role
Description	CV term Qualifiers & info Reference transposon P-element (Zhang et al., 2001)
Uses	CV term Qualifiers & info Reference binary system (targeted) Fmr1 (Zhang et al., 2001) characterization Fmr1 (Zhang et al., 2001)
Cloning Sites	Location Restriction sites Reference
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Extent
Segments & Size
Total Size
Left end
Right end

Segments	Number Orientation Symbol
Reference
Features
	CV term Qualifiers & info Reference binary component (Zhang et al., 2001)
Component Alleles
Allele	Fmr1^Scer\UAS.cZa
Reference(s)	(Zhang et al., 2001, Reeve et al., 2005, Morales et al., 2002, Pan et al., 2004, Bolduc et al., 2008, Reeve et al., 2008, Nechipurenko and Broihier, 2012, Sofola et al., 2007)
Molecular data	Construct: Expression of Fmr1 is governed by Scer\UAS regulatory sequences. (Zhang et al., 2001)
Phenotypic class	flightless, with Scer\GAL4^elav-C155 (Zhang et al., 2001) flightless, with Scer\GAL4^Mhc.PW (Zhang et al., 2001) lethal, with Fmr1^{I307N.Z.Scer\UAS}, Scer\GAL4^elav-C155 (Zhang et al., 2001) lethal \| adult stage, with Scer\GAL4^elav-C155 (Zhang et al., 2001) lethal \| pupal stage, with Scer\GAL4^G7 (Zhang et al., 2001) memory defective \| temperature conditional, with Scer\GAL4^hs.PB (Bolduc et al., 2008) neuroanatomy defective, with Scer\GAL4^ato.3.6 (Morales et al., 2002) neuroanatomy defective, with Scer\GAL4^c747 (Reeve et al., 2005) neuroanatomy defective, with Scer\GAL4^elav-C155 (Zhang et al., 2001) neuroanatomy defective, with Scer\GAL4^ey-OK107 (Pan et al., 2004) neuroanatomy defective, with Scer\GAL4^Mhc.PW (Zhang et al., 2001) neuroanatomy defective, with Scer\GAL4^P2.4.Pdf (Reeve et al., 2005) neuroanatomy defective \| somatic clone, with Scer\GAL4^ey-OK107 (Pan et al., 2004) neurophysiology defective, with Scer\GAL4^hs.2sev (Zhang et al., 2001) uncoordinated, with Scer\GAL4^elav-C155 (Zhang et al., 2001) visible, with Scer\GAL4^elav-C155 (Zhang et al., 2001)
Phenotype manifest in	adult mushroom body, with Scer\GAL4^c747 (Reeve et al., 2005) bouton, with Scer\GAL4^elav-C155 (Zhang et al., 2001) dorsal cluster neuron, with Scer\GAL4^ato.3.6 (Morales et al., 2002) eye photoreceptor cell, with Scer\GAL4^hs.2sev (Zhang et al., 2001) gamma-lobe & neuron \| somatic clone, with Scer\GAL4^ey-OK107 (Pan et al., 2004) LNv neuron, with Scer\GAL4^P2.4.Pdf (Reeve et al., 2005) mushroom body & neuron & dendrite \| somatic clone, with Scer\GAL4^ey-OK107 (Pan et al., 2004) mushroom body & neuron \| somatic clone, with Scer\GAL4^ey-OK107 (Pan et al., 2004) mushroom body beta'-lobe, with Scer\GAL4^ey-OK107 (Pan et al., 2004) mushroom body beta-lobe, with Scer\GAL4^ey-OK107 (Pan et al., 2004) mushroom body gamma-lobe, with Scer\GAL4^ey-OK107 (Pan et al., 2004) neuromuscular junction, with Scer\GAL4^elav-C155 (Zhang et al., 2001) neuromuscular junction, with Scer\GAL4^Mhc.PW (Zhang et al., 2001) ommatidium, with Scer\GAL4^hs.2sev (Zhang et al., 2001) photoreceptor cell & synapse & lamina receptor cell, with Scer\GAL4^hs.2sev (Zhang et al., 2001) retina, with Scer\GAL4^hs.2sev (Zhang et al., 2001) rhabdomere, with Scer\GAL4^hs.2sev (Zhang et al., 2001) wing, with Scer\GAL4^elav-C155 (Zhang et al., 2001) wing, with Scer\GAL4^Mhc.PW (Zhang et al., 2001)
Other information
Expression Data
Reporter Expression

Additional Information
Statement Reference

Marker for
Reflects expression of
Progenitors & Descendants
progenitor(s)
descendant(s)
Comments

Stocks Listed in FlyBase ( 1 )
Bloomington	6931 w¹¹¹⁸; P{UAS-Fmr1.Z}3
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs
Reported As
Symbol Synonym	fmr1^WT (Nechipurenko and Broihier, 2012) P(uasfmr1.Z) (Sofola et al., 2007) P{UAS-Fmr1.Z} (FlyBase, 1996-) UAS-dfmr (Pan et al., 2004) UAS-dfmr1 (Reeve et al., 2005, Reeve et al., 2008) UAS-dfxr (Morales et al., 2002) UAS-dFXR (Zhang et al., 2001) UAS-FMR+ (Bolduc et al., 2008)
Secondary FlyBase IDs

References ( 8 )
Research paper	Nechipurenko and Broihier, 2012, J. Cell Biol. 196(3): 345--362 FoxO limits microtubule stability and is itself negatively regulated by microtubule disruption. [FBrf0217391] Bolduc et al., 2008, Nat. Neurosci. 11(10): 1143--1145 Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory. [FBrf0206065] Reeve et al., 2008, J. Neurosci. 28(12): 3221--3226 Mutational analysis establishes a critical role for the N terminus of fragile X mental retardation protein FMRP. [FBrf0204382] Sofola et al., 2007, Neuron 55(4): 565--571 RNA-Binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS. [FBrf0200897] Reeve et al., 2005, Curr. Biol. 15(12): 1156--1163 The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain. [FBrf0187329] Pan et al., 2004, Curr. Biol. 14(20): 1863--1870 The Drosophila fragile X gene negatively regulates neuronal elaboration and synaptic differentiation. [FBrf0180069] Morales et al., 2002, Neuron 34(6): 961--972 Drosophila Fragile X protein, DFXR, regulates neuronal morphology and function in the brain. [FBrf0149142] Zhang et al., 2001, Cell 107(5): 591--603 Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. [FBrf0141416]