Recombinant construct P{UAS-imd.G}

General Information
Symbol	P{UAS-imd.G}	FlyBase ID	FBtp0015977
Feature type	transgenic_transposon

Size		Expression data
Associated insertions	0 available
Molecular map
Recent Updates
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FB2013_03
FB2013_02
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Description & Uses
Species	synthetic construct
Location-dependent role
Description	CV term Qualifiers & info Reference transposon P-element (Leulier et al., 2002)
Uses	CV term Qualifiers & info Reference binary system (targeted) imd (Leulier et al., 2002) characterization imd (Leulier et al., 2002)
Cloning Sites	Location Restriction sites Reference
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Extent
Segments & Size
Total Size
Left end
Right end

Segments	Number Orientation Symbol
Reference
Features
	CV term Qualifiers & info Reference binary component (Leulier et al., 2002)
Component Alleles
Allele	imd^Scer\UAS.cGa
Reference(s)	(Leulier et al., 2002, Kleino et al., 2005, Georgel et al., 2001, Kim et al., 2006, Foley and O'Farrell, 2003, Agaisse et al., 2003, Pal et al., 2007, Akhouayri et al., 2011, Wu et al., 2007, Buchon et al., 2009, Leulier et al., 2006, Thevenon et al., 2009)
Molecular data	Construct: Scer\UAS sequences drive expression of imd. (Leulier et al., 2002) Construct: Expression of the complete imd cDNA (GH20785) is under the control of Scer\UAS sequences. (Georgel et al., 2001)
Phenotypic class	increased cell death, with Scer\GAL4^hs.PB (Georgel et al., 2001) lethal \| larval stage, with Scer\GAL4^da.G32 (Georgel et al., 2001) radiation sensitive, with Scer\GAL4^hs.PB (Georgel et al., 2001) viable, with Scer\GAL4^hs.PB (Georgel et al., 2001)
Phenotype manifest in	embryonic/larval fat body, with Scer\GAL4^hs.PB (Georgel et al., 2001)
Other information
Expression Data
Reporter Expression

Additional Information
Statement Reference

Marker for
Reflects expression of
Progenitors & Descendants
progenitor(s)
descendant(s)
Comments

Stocks Listed in FlyBase ( 0 )

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs
Reported As
Symbol Synonym	(UAS)-imd (Leulier et al., 2006) IMD (Thevenon et al., 2009) P(UAS-imd) (Agaisse et al., 2003) P{UAS-imd.G} (FlyBase, 1996-) UAS-imd (Foley and O'Farrell, 2003, Wu et al., 2007, Buchon et al., 2009) UAS-Imd (Leulier et al., 2002, Pal et al., 2007, Kim et al., 2006) UAS-IMD (Akhouayri et al., 2011) UAS-imd.SN (Georgel et al., 2001)
Secondary FlyBase IDs

References ( 12 )
Research paper	Akhouayri et al., 2011, PLoS Pathog. 7(10): e1002319 Toll-8/tollo negatively regulates antimicrobial response in the Drosophila respiratory epithelium. [FBrf0216452] Buchon et al., 2009, Cell Host Microbe 5(2): 200--211 Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. [FBrf0206694] Thevenon et al., 2009, Cell Host Microbe 6(4): 309--320 The Drosophila ubiquitin-specific protease dUSP36/Scny targets IMD to prevent constitutive immune signaling. [FBrf0208983] Pal et al., 2007, J. Biol. Chem. 282(12): 8969--8977 Fungal peptide destruxin a plays a specific role in suppressing the innate immune response in Drosophila melanogaster. [FBrf0200357] Wu et al., 2007, Cell. Microbiol. 9(4): 1073--1085 ird1 is a Vps15 homologue important for antibacterial immune responses in Drosophila. [FBrf0201559] Kim et al., 2006, Proc. Natl. Acad. Sci. U.S.A. 103(44): 16358--16363 Caspar, a suppressor of antibacterial immunity in Drosophila. [FBrf0194794] Leulier et al., 2006, Mol. Cell. Biol. 26(21): 7821--7831 The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection. [FBrf0192381] Kleino et al., 2005, EMBO J. 24(19): 3423--3434 Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway. [FBrf0190362] Agaisse et al., 2003, Dev. Cell 5(3): 441--450 Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. [FBrf0162064] Foley and O'Farrell, 2003, Genes Dev. 17(1): 115--125 Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila. [FBrf0155482] Leulier et al., 2002, Curr. Biol. 12(12): 996--1000 Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults. [FBrf0151243] Georgel et al., 2001, Dev. Cell 1(4): 503--514 Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis. [FBrf0141455]