Recombinant construct P{UAS-cac1-EGFP}

General Information
Symbol	P{UAS-cac1-EGFP}	FlyBase ID	FBtp0019006
Feature type	transgenic_transposon

Size		Expression data
Associated insertions	4 available
Molecular map
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Description & Uses
Species	synthetic construct
Location-dependent role
Description	CV term Qualifiers & info Reference transposon P-element (Kawasaki et al., 2004)
Uses	CV term Qualifiers & info Reference binary system (targeted) cac (Kawasaki et al., 2004) characterization cac (Kawasaki et al., 2004) reporter construct vital \| cac (Kawasaki et al., 2004)
Cloning Sites	Location Restriction sites Reference
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Extent
Segments & Size
Total Size
Left end
Right end

Segments	Number Orientation Symbol
Reference
Features
	CV term Qualifiers & info Reference binary component (Kawasaki et al., 2004) molecular tag (Kawasaki et al., 2004)
Component Alleles
Allele	cac^{Scer\UAS.T:Avic\GFP-EGFP}
Reference(s)	(Kawasaki et al., 2004, Frank et al., 2009, Ly et al., 2008, Kittel et al., 2006, Fouquet et al., 2009, Yuan et al., 2011, Hallermann et al., 2010, Ryglewski et al., 2012, Liu et al., 2011, Long et al., 2008, Kurshan et al., 2009, Miśkiewicz et al., 2011, Dickman et al., 2008, Dickman and Davis, 2009, Graf et al., 2009, Johnson et al., 2009, Kawasaki and Ordway, 2009, Rasse et al., 2005, Kuromi et al., 2010, Graf et al., 2012)
Molecular data	Construct: Expression of cac tagged with T:Avic\GFP^EGFP is governed by Scer\UAS regulatory sequences. (Kawasaki et al., 2004)
Phenotypic class
Phenotype manifest in
Other information
Expression Data
Reporter Expression

Additional Information
Statement Reference

Marker for
Reflects expression of
Progenitors & Descendants
progenitor(s)
descendant(s)
Comments

Stocks Listed in FlyBase ( 3 )
Bloomington	8581 w^; P{UAS-cac1-EGFP}786C 8582 w^; P{UAS-cac1-EGFP}422A 8580 P{GawB}elav^C155 sd¹ f¹ P{UAS-cac1-EGFP}471/FM7i, P{ActGFP}JMR3
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs
Reported As
Symbol Synonym	cac^EGFP (Kuromi et al., 2010) Cac^GFP (Kittel et al., 2006, Rasse et al., 2005) CAC-GFP (Miśkiewicz et al., 2011) cacophony^EGFP (Kuromi et al., 2010) EGFP-CaV2.1 (Johnson et al., 2009) P{UAS-cac1-EGFP} (FlyBase, 1996-) UAS-cac1 (Ryglewski et al., 2012) UAS-cac1-EGFP (Kawasaki and Ordway, 2009) UAS-cac^EGFP (Kuromi et al., 2010) UAS-Cac^GFP (Hallermann et al., 2010) UAS-cacEGFP (Ly et al., 2008) UAS-Cac-GFP (Long et al., 2008) UAScacGFP (Dickman et al., 2008) UAS-cacGFP (Dickman and Davis, 2009) UAS-cac-gfp (Kurshan et al., 2009) UAS-Cacophony-GFP (Graf et al., 2009, Graf et al., 2012) UAS-GFP-cac (Frank et al., 2009)
Secondary FlyBase IDs

References ( 20 )
Research paper	Graf et al., 2012, J. Neurosci. 32(47): 16586--16596 RIM Promotes Calcium Channel Accumulation at Active Zones of the Drosophila Neuromuscular Junction. [FBrf0220028] Ryglewski et al., 2012, J. Physiol. 590(4): 809--825 Cav2 channels mediate low and high voltage-activated calcium currents in Drosophila motoneurons. [FBrf0217496] Liu et al., 2011, Science 334(6062): 1565--1569 RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release. [FBrf0216992] Miśkiewicz et al., 2011, Neuron 72(5): 776--788 ELP3 Controls Active Zone Morphology by Acetylating the ELKS Family Member Bruchpilot. [FBrf0216903] Yuan et al., 2011, Science 333(6048): 1458--1462 Light-induced structural and functional plasticity in Drosophila larval visual system. [FBrf0215276] Hallermann et al., 2010, J. Neurosci. 30(43): 14340--14345 Naked dense bodies provoke depression. [FBrf0214096] Kuromi et al., 2010, Europ. J. Neurosci. 32(3): 335--346 Two types of Ca channel linked to two endocytic pathways coordinately maintain synaptic transmission at the Drosophila synapse. [FBrf0211498] Dickman and Davis, 2009, Science 326(5956): 1127--1130 The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis. [FBrf0209454] Fouquet et al., 2009, J. Cell Biol. 186(1): 129--145 Maturation of active zone assembly by Drosophila Bruchpilot. [FBrf0208461] Frank et al., 2009, Neuron 61(4): 556--569 A presynaptic homeostatic signaling system composed of the Eph receptor, ephexin, Cdc42, and CaV2.1 calcium channels. [FBrf0207531] Graf et al., 2009, Neuron 64(5): 663--677 Rab3 Dynamically Controls Protein Composition at Active Zones. [FBrf0209504] Johnson et al., 2009, PLoS Biol. 7(9): e1000193 Negative regulation of active zone assembly by a newly identified SR protein kinase. [FBrf0208771] Kawasaki and Ordway, 2009, Proc. Natl. Acad. Sci. U.S.A. 106(34): 14658--14663 Molecular mechanisms determining conserved properties of short-term synaptic depression revealed in NSF and SNAP-25 conditional mutants. [FBrf0208709] Kurshan et al., 2009, Nat. Neurosci. 12(11): 1415--1423 Presynaptic alpha(2)delta-3 is required for synaptic morphogenesis independent of its Ca(2+)-channel functions. [FBrf0209005] Dickman et al., 2008, J. Neurosci. 28(1): 31--38 Mutations in a drosophila alpha(2)delta voltage-gated calcium channel subunit reveal a crucial synaptic function. [FBrf0202120] Long et al., 2008, J. Neurosci. 28(14): 3668--3682 Presynaptic calcium channel localization and calcium-dependent synaptic vesicle exocytosis regulated by the Fuseless protein. [FBrf0204409] Ly et al., 2008, J. Cell Biol. 181(1): 157--170 straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit. [FBrf0204125] Kittel et al., 2006, Science 312(5776): 1051--1054 Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release. [FBrf0190611] Rasse et al., 2005, Nat. Neurosci. 8(7): 898--905 Glutamate receptor dynamics organizing synapse formation in vivo. [FBrf0188163] Kawasaki et al., 2004, J. Neurosci. 24(1): 282--285 Active zone localization of presynaptic calcium channels encoded by the cacophony locus of Drosophila. [FBrf0167806]