Recombinant construct P{UAS-Hsap\MAPT.E14}

General Information
Symbol	P{UAS-Hsap\MAPT.E14}	FlyBase ID	FBtp0055829
Feature type	transgenic_transposon

Size		Expression data
Associated insertions	0 available
Molecular map
Recent Updates
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FB2013_03
FB2013_02	Controlled Vocabulary Terms neuroanatomy defective adult mushroom body
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Description & Uses
Species	synthetic construct
Location-dependent role
Description	CV term Qualifiers & info Reference transposon P-element (Loewen and Feany, 2010)
Uses	CV term Qualifiers & info Reference
Cloning Sites	Location Restriction sites Reference
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Extent
Segments & Size
Total Size
Left end
Right end

Segments	Number Orientation Symbol
Reference
Features
	CV term Qualifiers & info Reference
Component Alleles
Allele	Hsap\MAPT^E14.Scer\UAS
Reference(s)	(Khurana et al., 2006, Nezis et al., 2008, Fulga et al., 2007, Loewen and Feany, 2010, Yeh et al., 2010, Duboff et al., 2012, Kosmidis et al., 2010)
Molecular data	Scer\UAS regulatory sequences drive expression of Hsap\MAPT, carrying mutations in fourteen disease-associated Ser-Thr-Pro sites (Thr 111, Thr 153, Ser 175, Thr 181, Ser 199, Ser 202, Thr 205, Thr 212, Thr 217, Thr 231, Ser 235, Ser 396, Ser 404, and Ser 422) to glutamate. (Khurana et al., 2006)
Phenotypic class	neuroanatomy defective, with Scer\GAL4^elav.PU (Kosmidis et al., 2010)
Phenotype manifest in	adult brain, with Scer\GAL4^elav.PLu (Khurana et al., 2006) adult brain, with Scer\GAL4^elav.PU (Duboff et al., 2012) adult mushroom body, with Scer\GAL4^elav.PU (Kosmidis et al., 2010) eye, with Scer\GAL4^GMR.PF (Khurana et al., 2006, Fulga et al., 2007, Yeh et al., 2010) macrochaeta, with Scer\GAL4^Eq1 (Yeh et al., 2010) mitochondrion, with Scer\GAL4^elav.PU (Duboff et al., 2012) sensory organ cell, with Scer\GAL4^Eq1 (Yeh et al., 2010)
Other information
Expression Data
Reporter Expression

Additional Information
Statement Reference

Marker for
Reflects expression of
Progenitors & Descendants
progenitor(s)
descendant(s)
Comments

Stocks Listed in FlyBase ( 0 )

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs
Reported As
Symbol Synonym	P{UAS-Hsap\MAPT.E14} (FlyBase, 1992-) tau^E14 (Loewen and Feany, 2010) UAS-E14 (Nezis et al., 2008) UAS-htau^0N4R-E14 (Kosmidis et al., 2010) UAS-hTau^E14 (Yeh et al., 2010) UAS-tau^E14 (Khurana et al., 2006, Fulga et al., 2007, Duboff et al., 2012)
Secondary FlyBase IDs

References ( 7 )
Research paper	Duboff et al., 2012, Neuron 75(4): 618--632 Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo. [FBrf0219271] Kosmidis et al., 2010, J. Neurosci. 30(2): 464--477 Differential effects of Tau on the integrity and function of neurons essential for learning in Drosophila. [FBrf0215006] Loewen and Feany, 2010, PLoS ONE 5(9): e13084 The unfolded protein response protects from tau neurotoxicity in vivo. [FBrf0211994] Yeh et al., 2010, Biochem. Biophys. Res. Commun. 391(1): 510--516 Drosophila notal bristle as a novel assessment tool for pathogenic study of Tau toxicity and screening of therapeutic compounds. [FBrf0209785] Nezis et al., 2008, J. Cell Biol. 180(6): 1065--1071 Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain. [FBrf0204151] Fulga et al., 2007, Nat. Cell Biol. 9(2): 139--148 Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. [FBrf0193954] Khurana et al., 2006, Curr. Biol. 16(3): 230--241 TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model. [FBrf0190026]