Evolutionary signatures for protein-coding genes

By studying evolution, we found this:

Revisiting the D. melanogaster protein-coding gene catalog

Purpose here is not to study gene evolution (see Eisen paper), but rather to leverage the 12 genomes to improve gene annotation quality.


Discovery of non-canonical genic phenomena

Conserved non-coding regions

Gene regulation

Discussion:  Assessing power to identify functional elements with 12 genomes