Aaron, 1979, Mutat. Res. 63: 127--137

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Aaron, 1979, Mutat. Res. 63: 127--137
FlyBase Identifier FBrf0033674
FlyBase URL http://flybase.org/reports/FBrf0033674.html
Publication Type paper
Publication Year 1979
PubMed ID 118372
PubMed URL http://www.ncbi.nlm.nih.gov/pubmed/118372


X-ray-induced mutations affecting the level of the enzyme alcohol dehydrogenase in Drosophila melanogaster: frequency and genetic analysis of null-enzyme mutants.


The frequency of X-ray-induced (null-enzyme) mutations at the alcohol dehydrogenase locus in Drosophila melanogaster was measured. The rate of recovery of chromosomes that fail to direct the synthesis of a functional Adh protein is 3 x 10(-8) per R for chromosomes that do not include large chromosome rearrangements. However, this analysis excludes a larger number of chromosomes that are "null-enzyme mutations" because thye are deleted for the region of the Adh locus. The dose of X-rays required to induce a frequency of non-deletion null-enzyme mutants equal to the spontaneous frequency is about 73 rad calculated from the data reported in this communication.

Genes from Reference

Gene(s) Dmel\Adh
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