Adler and Lee, 2001, Curr. Opin. Cell Biol. 13(5): 635--640

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Adler and Lee, 2001, Curr. Opin. Cell Biol. 13(5): 635--640
FlyBase Identifier FBrf0138274
FlyBase URL http://flybase.org/reports/FBrf0138274.html
Publication Type review
Publication Year 2001
PubMed ID 11544034
PubMed URL http://www.ncbi.nlm.nih.gov/pubmed/11544034

Title

Frizzled signaling and cell-cell interactions in planar polarity.

Abstract

The function of the Frizzled pathway is essential for the formation of the array of distally pointing hairs found on the Drosophila wing. Previous research found that regulating the subcellular location for hair initiation controlled hair polarity. Recent work argues a graded Frizzled-dependent signal results in the accumulation of the Frizzled, Dishevelled and Flamingo proteins along the distal edge of the wing cells. This cortical mark leads to the local activation of downstream gene products and the subsequent activation of the cytoskeleton to form a hair.

Genes from Reference

Gene(s) Dmel\Dl
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