Affolter et al., 2003, Dev. Cell 4(1): 11--18

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Affolter et al., 2003, Dev. Cell 4(1): 11--18
FlyBase Identifier FBrf0155681
FlyBase URL http://flybase.org/reports/FBrf0155681.html
Publication Type review
Publication Year 2003
PubMed ID 12530959
PubMed URL http://www.ncbi.nlm.nih.gov/pubmed/12530959

Title

Tube or not tube. Remodeling epithelial tissues by branching morphogenesis.

Abstract

Branching morphogenesis involves the restructuring of epithelial tissues into complex and organized ramified tubular networks. Early rounds of branching are controlled genetically in a hardwired fashion in many organs, whereas later, branching is stochastic, responding to environmental cues. We discuss this sequential process from formation of an organ anlage and invagination of the epithelium to branch initiation and outgrowth in several model systems including Drosophila trachea and mammalian lung, mammary gland, and kidney.

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Gene(s) Dmel\dpp
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