Aigaki et al., 2002, Mech. Ageing Dev. 123(12): 1531--1541

Aigaki et al., 2002, Mech. Ageing Dev. 123(12): 1531--1541
FlyBase Identifier	FBrf0155931
FlyBase URL	http://flybase.org/reports/FBrf0155931.html
Publication Type	review
Publication Year	2002
PubMed ID	12470891
PubMed URL	http://www.ncbi.nlm.nih.gov/pubmed/12470891

Title

Longevity determination genes in Drosophila melanogaster.

Abstract

Identification of longevity mutants is crucial for genetic approach to dissect the molecular mechanism of aging and longevity determination. In Drosophila melanogaster, several mutations have been shown to extend the longevity: methuselah encoding a putative G-protein coupled receptor, Indy encoding a sodium dicarboxylate cotransporter, chico encoding insulin receptor substrate, and InR encoding the insulin-like receptor. Extended longevity phenotypes were also observed in transgenic flies overexpressing antioxidant enzymes, Cu/Zn superoxide dismutase and Catalase, Cu/Zn SOD only, or a molecular chaperone, hsp70. Pleiotropism of mutations is a limitation associated with conventional mutagenesis for efficient detection of longevity determination genes. Using a conditional misexpression system, we identified Drosophila POSH (DPOSH), a scaffold protein containing RING finger and four SH3 domains, whose ubiquitous overexpression in adult stage extends the longevity. Neural-specific overexpression of DPOSH is sufficient to extend the longevity, whereas overexpression in non-neural tissues during development induces apoptosis through activation of JNK/SAPK pathway.

Genes from Reference

Gene(s)	Dmel\dpp