Albalat et al., 1994, Genetica 94(1): 27--36

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Albalat et al., 1994, Genetica 94(1): 27--36
FlyBase Identifier FBrf0079843
FlyBase URL
Publication Type paper
Publication Year 1994
PubMed ID 7729694
PubMed URL


Analysis of nucleotide substitutions and amino acid conservation in the Drosophila Adh genomic region.


The homologous genomic region that contains two paralogous genes, Adh and Adh-dup, was compared in several Drosophila species. Sequences were analyzed as follows: a) At the nucleotide level, Ka and Ks values were determined for each pair of species. Ka-Adh and Ka-Adh-dup are not significantly different. However, Ks-Adh values are significantly lower than Ks-Adh-dup, which are more variable. In agreement with other reports, lower Ks values for Adh correlate with a high level of gene expression and relatively high percentage of G+C content in the third codon position, while the opposite applies to Adh-dup. b) At the protein level, amino acid comparisons reveal conserved regions shared by ADH and ADH-DUP, which have been assigned to known functional domains. Key residues for dehydrogenasic function are also found in ADH-DUP, thus pointing to a dehydrogenase activity for ADH-DUP, albeit very different from that of ADH.

Genes from Reference

Gene(s) Dmel\Adh
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