This wiki is being tested. With FB2013_01, released January 23rd, 2013, FlyBase is testing this wiki for gene summarization as part of our community curation effort. A more formal release is planned for FB2013_06, scheduled November 1st, 2013. Please help us by sending in feedback using this form.

Alekseyenko et al., 2006, Genes Dev. 20(7): 848--857

From FlyBase Wiki
Jump to: navigation, search
Alekseyenko et al., 2006, Genes Dev. 20(7): 848--857
FlyBase Identifier FBrf0190534
FlyBase URL http://flybase.org/reports/FBrf0190534.html
Publication Type paper
Publication Year 2006
PubMed ID 16547173
PubMed URL http://www.ncbi.nlm.nih.gov/pubmed/16547173

Title

High-resolution ChIP-chip analysis reveals that the Drosophila MSL complex selectively identifies active genes on the male X chromosome.

Abstract

X-chromosome dosage compensation in Drosophila requires the male-specific lethal (MSL) complex, which up-regulates gene expression from the single male X chromosome. Here, we define X-chromosome-specific MSL binding at high resolution in two male cell lines and in late-stage embryos. We find that the MSL complex is highly enriched over most expressed genes, with binding biased toward the 3' end of transcription units. The binding patterns are largely similar in the distinct cell types, with approximately 600 genes clearly bound in all three cases. Genes identified as clearly bound in one cell type and not in another indicate that attraction of MSL complex correlates with expression state. Thus, sequence alone is not sufficient to explain MSL targeting. We propose that the MSL complex recognizes most X-linked genes, but only in the context of chromatin factors or modifications indicative of active transcription. Distinguishing expressed genes from the bulk of the genome is likely to be an important function common to many chromatin organizing and modifying activities.

Genes from Reference

Gene(s) Dmel\w
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox