Alphey, 2002, Insect Biochem. Mol. Biol. 32(10): 1243--1247

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Alphey, 2002, Insect Biochem. Mol. Biol. 32(10): 1243--1247
FlyBase Identifier FBrf0155841
FlyBase URL
Publication Type review
Publication Year 2002
PubMed ID 12225915
PubMed URL


Re-engineering the sterile insect technique.


The mass release of sterile insects (the Sterile Insect Technique, SIT) is a highly effective area-wide method of pest control with a low environmental impact. SIT relies on the sterilization by irradiation of large numbers of insects. This has unavoidable costs in terms of the fitness of the irradiated insects and the financial requirements of constructing and operating the radiation facility. In many cases it is considered important to release only males, but large-scale sex-separation is also problematic. I have proposed that both of these difficulties can be overcome by using engineered strains of insects carrying a dominant, repressible, lethal gene or genetic system. As a proof of principle, my group and others have constructed strains of Drosophila melanogaster with the required genetic properties.

Genes from Reference

Gene(s) Dmel\W
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