Ambegaokar and Jackson, 2010, Genetics 186(1): 435--442
|Ambegaokar and Jackson, 2010, Genetics 186(1): 435--442|
Interaction Between Eye Pigment Genes and Tau-Induced Neurodegeneration in Drosophila melanogaster.
Null mutations in the genes white and brown, but not scarlet, enhance a rough eye phenotype in a Drosophila melanogaster model of tauopathy; however, adding rosy mutations suppresses these effects. Interaction with nucleotide-derived pigments or increased lysosomal dysregulation are potential mechanisms. Finally, tau toxicity correlates with increased GSK-3β activity, but not with tau phosphorylation at Ser202/Thr205.
Genes from Reference