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Ambegaokar and Jackson, 2010, Genetics 186(1): 435--442
| Ambegaokar and Jackson, 2010, Genetics 186(1): 435--442 | |
|---|---|
| FlyBase Identifier | FBrf0211818 |
| FlyBase URL | http://flybase.org/reports/FBrf0211818.html |
| Publication Type | paper |
| Publication Year | 2010 |
| PubMed ID | 20592261 |
| PubMed URL | http://www.ncbi.nlm.nih.gov/pubmed/20592261 |
Title
Interaction Between Eye Pigment Genes and Tau-Induced Neurodegeneration in Drosophila melanogaster.
Abstract
Null mutations in the genes white and brown, but not scarlet, enhance a rough eye phenotype in a Drosophila melanogaster model of tauopathy; however, adding rosy mutations suppresses these effects. Interaction with nucleotide-derived pigments or increased lysosomal dysregulation are potential mechanisms. Finally, tau toxicity correlates with increased GSK-3β activity, but not with tau phosphorylation at Ser202/Thr205.
Genes from Reference
| Gene(s) | Dmel\w |
|---|
