Ambegaokar and Jackson, 2010, Genetics 186(1): 435--442

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Ambegaokar and Jackson, 2010, Genetics 186(1): 435--442
FlyBase Identifier FBrf0211818
FlyBase URL http://flybase.org/reports/FBrf0211818.html
Publication Type paper
Publication Year 2010
PubMed ID 20592261
PubMed URL http://www.ncbi.nlm.nih.gov/pubmed/20592261

Title

Interaction Between Eye Pigment Genes and Tau-Induced Neurodegeneration in Drosophila melanogaster.

Abstract

Null mutations in the genes white and brown, but not scarlet, enhance a rough eye phenotype in a Drosophila melanogaster model of tauopathy; however, adding rosy mutations suppresses these effects. Interaction with nucleotide-derived pigments or increased lysosomal dysregulation are potential mechanisms. Finally, tau toxicity correlates with increased GSK-3β activity, but not with tau phosphorylation at Ser202/Thr205.

Genes from Reference

Gene(s) Dmel\w
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