Amin et al., 1999, Development 126(12): 2623--2630

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Amin et al., 1999, Development 126(12): 2623--2630
FlyBase Identifier FBrf0108570
FlyBase URL
Publication Type paper
Publication Year 1999
PubMed ID 10331974
PubMed URL


Hedgehog activates the EGF receptor pathway during Drosophila head development.


The Hedgehog (Hh) and Epidermal growth factor receptor (EGFR) signaling pathways play critical roles in pattern formation and cell proliferation in invertebrates and vertebrates. In this study, we demonstrate a direct link between these two pathways in Drosophila melanogaster. Hh and EGFR signaling are each required for the formation of a specific region of the head of the adult fruitfly. We show that hh and vein (vn), which encodes a ligand of the Drosophila EGFR (Schnepp, B., Grumbling, G., Donaldson, T. and Simcox, A. (1996) Genes Dev. 10, 2302-13), are expressed in adjacent domains within the imaginal primordium of this region. Using loss- and gain-of-function approaches, we demonstrate that Hh activates vn expression. We also show that Hh activation of vn is mediated through the gene cubitus interruptus (ci) and that this activation requires the C-terminal region of the Ci protein. Finally, we demonstrate that wingless (wg) represses vn expression, thereby limiting the domain of EGFR signaling.

Genes from Reference

Gene(s) Dmel\vn, Dmel\w
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