To return to FlyBase, see FlyBase Gene Report: Dmel\Npc1b.
|Name||Niemann-Pick type C-1b|
The gene Niemann-Pick type C-1b is referred to in FlyBase by the symbol Dmel\Npc1b (CG12092, FBgn0261675). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: hedgehog receptor activity. There is experimental evidence that it is involved in the biological process: central nervous system development; dorsal closure; intestinal cholesterol absorption; peripheral nervous system development. 37 alleles are reported. The phenotypes of these alleles are annotated with: dorsal closure embryo; embryonic/first instar larval cuticle; embryonic head; trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Patched; Sterol-sensing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult midgut. Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut. Comments on Affy2 ProbeSet: ProbeSet 1632659_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Npc1b. Gene sequence location is X:20805980..20810408.