To return to FlyBase, see FlyBase Gene Report: Dmel\TSG101.
|Name||tumor suppressor protein 101|
The gene tumor suppressor protein 101 is referred to in FlyBase by the symbol Dmel\TSG101 (CG9712, FBgn0036666). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: negative regulation of growth; trachea morphogenesis; terminal branching, open tracheal system; negative regulation of growth of symbiont in host; regulation of JAK-STAT cascade; negative regulation of imaginal disc growth; maintenance of apical/basal cell polarity. 12 alleles are reported. The phenotypes of these alleles are annotated with: yolk granule; oocyte; embryonic/larval tracheal system; terminal tracheal cell; vesicle. It has one annotated transcript and one annotated polypeptide. Protein features are: Steadiness box; Ubiquitin E2 variant, N-terminal; Ubiquitin-conjugating enzyme/RWD-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during late larval stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval/adult Malpighian tubules, adult heart, larval fat body, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult brain, adult crop, larval/adult midgut, larval/adult hindgut, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640247_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of TSG101. Gene sequence location is 3L:16835394..16837685.