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This gene article is a stub. It has been seeded with the automatically generated summary from FlyBase release FB2013_02. Please help improve this summary by logging in and editing it.

To return to FlyBase, see FlyBase Gene Report: Dmel\TSG101.

Symbol Dmel\TSG101
Name tumor suppressor protein 101
Species Drosophila melanogaster
Annotation symbol CG9712
FlyBase ID FBgn0036666

The gene tumor suppressor protein 101 is referred to in FlyBase by the symbol Dmel\TSG101 (CG9712, FBgn0036666). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: negative regulation of growth; trachea morphogenesis; terminal branching, open tracheal system; negative regulation of growth of symbiont in host; regulation of JAK-STAT cascade; negative regulation of imaginal disc growth; maintenance of apical/basal cell polarity. 12 alleles are reported. The phenotypes of these alleles are annotated with: yolk granule; oocyte; embryonic/larval tracheal system; terminal tracheal cell; vesicle. It has one annotated transcript and one annotated polypeptide. Protein features are: Steadiness box; Ubiquitin E2 variant, N-terminal; Ubiquitin-conjugating enzyme/RWD-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during late larval stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval/adult Malpighian tubules, adult heart, larval fat body, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult brain, adult crop, larval/adult midgut, larval/adult hindgut, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640247_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of TSG101. Gene sequence location is 3L:16835394..16837685.


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