Dmel\mgl

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Dmel\mgl
Identifiers
Symbol	Dmel\mgl
Name	Megalin
Species	Drosophila melanogaster
Annotation symbol	CG42611
FlyBase ID	FBgn0261260

The gene Megalin is referred to in FlyBase by the symbol Dmel\mgl (CG42611, FBgn0261260). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: low-density lipoprotein receptor activity. There is experimental evidence that it is involved in the biological process: chitin-based cuticle development; regulation of endocytosis; regulation of adult chitin-containing cuticle pigmentation. 33 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; adult cuticle; procuticle; wing blade. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Complement Clr-like EGF domain; EGF-like calcium-binding; EGF-like calcium-binding, conserved site; EGF-like, conserved site; EGF-type aspartate/asparagine hydroxylation site; Epidermal growth factor-like domain; Growth factor, receptor; LDLR class B repeat; Low-density lipoprotein (LDL) receptor class A repeat; Low-density lipoprotein (LDL) receptor class A, conserved site; Six-bladed beta-propeller, TolB-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, adult crop, larval hindgut, larval trachea, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult hindgut, larval Malpighian tubules, adult salivary gland, adult ovary, adult testis, larval/adult carcass. Gene sequence location is X:9253877..9394162.