To return to FlyBase, see FlyBase Gene Report: Dmel\mgl.
The gene Megalin is referred to in FlyBase by the symbol Dmel\mgl (CG42611, FBgn0261260). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: low-density lipoprotein receptor activity. There is experimental evidence that it is involved in the biological process: chitin-based cuticle development; regulation of endocytosis; regulation of adult chitin-containing cuticle pigmentation. 33 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; adult cuticle; procuticle; wing blade. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Complement Clr-like EGF domain; EGF-like calcium-binding; EGF-like calcium-binding, conserved site; EGF-like, conserved site; EGF-type aspartate/asparagine hydroxylation site; Epidermal growth factor-like domain; Growth factor, receptor; LDLR class B repeat; Low-density lipoprotein (LDL) receptor class A repeat; Low-density lipoprotein (LDL) receptor class A, conserved site; Six-bladed beta-propeller, TolB-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, adult crop, larval hindgut, larval trachea, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult hindgut, larval Malpighian tubules, adult salivary gland, adult ovary, adult testis, larval/adult carcass. Gene sequence location is X:9253877..9394162.