FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term exacerbates ID (Ontology) FBcv:0003005 (FlyBase CV)
Definition Makes a condition worse.
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  HUMAN_DISEASE_INTERACTIONS    2362
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Alleles
 exacerbates (all annotations which use CV term, excluding "NOT" statements)    2362
     exacerbates | acute myeloid leukemia      29
     exacerbates | adult-onset myofibrillar myopathy 2A       1
     exacerbates | alcohol use disorder       2
     exacerbates | Alexander disease       4
     exacerbates | alveolar rhabdomyosarcoma       1
     exacerbates | Alzheimer's disease      69
     exacerbates | Alzheimer's disease 1      97
     exacerbates | amyotrophic lateral sclerosis      38
     exacerbates | amyotrophic lateral sclerosis type 1       5
     exacerbates | amyotrophic lateral sclerosis type 10      87
     exacerbates | amyotrophic lateral sclerosis type 15       4
     exacerbates | amyotrophic lateral sclerosis type 2       2
     exacerbates | amyotrophic lateral sclerosis type 21       7
     exacerbates | amyotrophic lateral sclerosis type 6      36
     exacerbates | amyotrophic lateral sclerosis type 8      58
     exacerbates | ataxia telangiectasia       3
     exacerbates | atypical teratoid rhabdoid tumor      87
     exacerbates | autism spectrum disorder       9
     exacerbates | autosomal dominant cerebellar ataxia      54
     exacerbates | autosomal recessive intellectual developmental disorder       4
     exacerbates | autosomal recessive intellectual developmental disorder 56       2
     exacerbates | autosomal recessive nonsyndromic deafness 2       1
     exacerbates | Bloom syndrome       1
     exacerbates | brain cancer      21
     exacerbates | brain glioma       3
     exacerbates | brain ischemia       1
     exacerbates | C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis     136
     exacerbates | cancer     225
     exacerbates | carcinoma     102
     exacerbates | central nervous system cancer       2
     exacerbates | cerebellar ataxia       1
     exacerbates | Charcot-Marie-Tooth disease       3
     exacerbates | Charcot-Marie-Tooth disease dominant intermediate C       8
     exacerbates | Charcot-Marie-Tooth disease type 2       5
     exacerbates | Charcot-Marie-Tooth disease type 2D       2
     exacerbates | Charcot-Marie-Tooth disease type 4B1       3
     exacerbates | childhood spinal muscular atrophy      11
     exacerbates | chromosome 16p11.2 deletion syndrome, 593-kb       1
     exacerbates | chronic myeloid leukemia       4
     exacerbates | classic galactosemia       1
     exacerbates | coenzyme Q10 deficiency disease       1
     exacerbates | colorectal cancer       2
     exacerbates | combined saposin deficiency       1
     exacerbates | congenital disorder of deglycosylation 1       5
     exacerbates | congenital disorder of glycosylation Ij       1
     exacerbates | congenital generalized lipodystrophy       5
     exacerbates | congenital heart disease       1
     exacerbates | congenital muscular dystrophy due to LMNA mutation       4
     exacerbates | congenital muscular dystrophy-dystroglycanopathy type A1       1
     exacerbates | Creutzfeldt-Jakob disease       2
     exacerbates | cytochrome-c oxidase deficiency disease       1
     exacerbates | dentatorubral-pallidoluysian atrophy       5
     exacerbates | developmental and epileptic encephalopathy 4       2
     exacerbates | developmental and epileptic encephalopathy 64       3
     exacerbates | diffuse midline glioma, H3 K27M-mutant       1
     exacerbates | dilated cardiomyopathy 1A       1
     exacerbates | Down syndrome       1
     exacerbates | Emery-Dreifuss muscular dystrophy       1
     exacerbates | epilepsy       7
     exacerbates | Epstein-Barr virus hepatitis      33
     exacerbates | erythrokeratodermia variabilis       1
     exacerbates | fragile X syndrome       4
     exacerbates | fragile X-associated tremor/ataxia syndrome      37
     exacerbates | Friedreich ataxia       1
     exacerbates | Friedreich ataxia 1       1
     exacerbates | frontotemporal dementia      34
     exacerbates | frontotemporal dementia and/or amyotrophic lateral sclerosis 2      16
     exacerbates | frontotemporal dementia and/or amyotrophic lateral sclerosis 6       3
     exacerbates | frontotemporal dementia and/or amyotrophic lateral sclerosis 7      18
     exacerbates | galactosemia       4
     exacerbates | Galloway-Mowat syndrome 3       1
     exacerbates | gastrointestinal system cancer       3
     exacerbates | Gaucher's disease       2
     exacerbates | germ cell cancer       1
     exacerbates | heart conduction disease       1
     exacerbates | hematologic cancer      22
     exacerbates | hereditary spastic paraplegia       2
     exacerbates | hereditary spastic paraplegia 3A       2
     exacerbates | hereditary spastic paraplegia 4       1
     exacerbates | hereditary spastic paraplegia 61       2
     exacerbates | hereditary systemic amyloidosis 1       1
     exacerbates | Hermansky-Pudlak syndrome       6
     exacerbates | high grade glioma       9
     exacerbates | human immunodeficiency virus infectious disease       3
     exacerbates | Huntington's disease     202
     exacerbates | hypoplastic left heart syndrome       3
     exacerbates | inclusion body myopathy with Paget disease of bone and frontotemporal dementia       2
     exacerbates | infectious mononucleosis      33
     exacerbates | intestinal cancer      13
     exacerbates | juvenile polyposis syndrome       1
     exacerbates | Kennedy's disease      14
     exacerbates | Kufor-Rakeb syndrome       3
     exacerbates | leukemia       1
     exacerbates | Lewy body dementia       1
     exacerbates | Machado-Joseph disease     104
     exacerbates | microcephaly       3
     exacerbates | mitochondrial DNA depletion syndrome 15       8
     exacerbates | mitochondrial encephalomyopathy       1
     exacerbates | mitochondrial metabolism disease       3
     exacerbates | motor neuron disease       1
     exacerbates | mucolipidosis type IV       3
     exacerbates | mucopolysaccharidosis type IIIA       7
     exacerbates | multiple endocrine neoplasia type 1       2
     exacerbates | multiple endocrine neoplasia type 2A       9
     exacerbates | multiple endocrine neoplasia type 2B      16
     exacerbates | muscular dystrophy      29
     exacerbates | muscular dystrophy-dystroglycanopathy       4
     exacerbates | myopathy       2
     exacerbates | myotonic dystrophy type 1       3
     exacerbates | myotonic dystrophy type 2       1
     exacerbates | nemaline myopathy 7       1
     exacerbates | neonatal diabetes mellitus       4
     exacerbates | nephrotic syndrome       2
     exacerbates | nervous system disease      13
     exacerbates | neurodegenerative disease     112
     exacerbates | neurofibromatosis       9
     exacerbates | neuromuscular disease       2
     exacerbates | neuronal ceroid lipofuscinosis       7
     exacerbates | neuronal ceroid lipofuscinosis 4       3
     exacerbates | neuronal ceroid lipofuscinosis 7       3
     exacerbates | neuronal intranuclear inclusion disease       2
     exacerbates | obesity      12
     exacerbates | oculopharyngeal muscular dystrophy       2
     exacerbates | olivopontocerebellar atrophy      21
     exacerbates | pantothenate kinase-associated neurodegeneration       1
     exacerbates | Parkinson's disease      86
     exacerbates | Parkinson's disease 1      77
     exacerbates | Parkinson's disease 2      14
     exacerbates | Parkinson's disease 22       1
     exacerbates | Parkinson's disease 6      22
     exacerbates | Parkinson's disease 8      16
     exacerbates | Perlman syndrome       1
     exacerbates | porphyria       1
     exacerbates | primary autosomal dominant microcephaly 18       2
     exacerbates | primary autosomal recessive microcephaly 2 with or without cortical malformations       1
     exacerbates | primary autosomal recessive microcephaly 5       1
     exacerbates | primary coenzyme Q10 deficiency 1       2
     exacerbates | prion disease       9
     exacerbates | retinal degeneration       1
     exacerbates | retinal disease       5
     exacerbates | retinitis pigmentosa      10
     exacerbates | retinitis pigmentosa 4       8
     exacerbates | Schimke immuno-osseous dysplasia       1
     exacerbates | schizophrenia       1
     exacerbates | sensorineural hearing loss       2
     exacerbates | sensory system disease       1
     exacerbates | severe acute respiratory syndrome       5
     exacerbates | Shwachman-Diamond syndrome       1
     exacerbates | spinocerebellar ataxia 1       5
     exacerbates | spinocerebellar ataxia 2       3
     exacerbates | spinocerebellar ataxia 31       4
     exacerbates | spinocerebellar ataxia 5       2
     exacerbates | spinocerebellar ataxia 6       2
     exacerbates | spinocerebellar ataxia 8       1
     exacerbates | syndrome       1
     exacerbates | syndromic intellectual disability       1
     exacerbates | synucleinopathy       2
     exacerbates | tauopathy     381
     exacerbates | Troyer syndrome       3
     exacerbates | tuberous sclerosis       9
     exacerbates | viral infectious disease      33
     exacerbates | Vissers-Bodmer syndrome       7
     exacerbates | Walker-Warburg syndrome       1
     exacerbates | Wolfram syndrome 1       1
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