FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term molecular_function ID (Ontology) GO:0003674 (Gene Ontology)
Definition A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
Also Known As "molecular function"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION    3025
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 molecular_function (all annotations which use CV term, excluding "NOT" statements)    3117
     enables | molecular_function    3025
Spanning Tree (Parents/Children)
Only view relationship: 
  molecular_function  14444 rec.
   |__antioxidant activity 63 rec.
   |   |__glutathione dehydrogenase (ascorbate) activity 5 rec.
   |   |__glutathione-disulfide reductase (NADPH) activity
   |   |__peroxidase activity(+) 48 rec.
   |   |__sulfiredoxin activity 1 rec.
   |   |__superoxide dismutase activity 5 rec.
   |   |__superoxide reductase activity
   |   |__thioredoxin-disulfide reductase (NADPH) activity 4 rec.
   |__ATP-dependent activity 505 rec.
   |   |__ATP hydrolysis activity 234 rec.
   |   |__ATP-dependent activity, acting on DNA(+) 88 rec.
   |   |__ATP-dependent activity, acting on RNA(+) 63 rec.
   |   |__ATP-dependent FeS chaperone activity 4 rec.
   |   |__ATP-dependent peptidase activity 7 rec.
   |   |__ATP-dependent protein disaggregase activity 1 rec.
   |   |__ATP-dependent protein folding chaperone 38 rec.
   |   |__ATPase-coupled intramembrane lipid transporter activity(+) 10 rec.
   |   |__ATPase-coupled transmembrane transporter activity(+) 123 rec.
   |   |__calcium-dependent ATPase activity 1 rec.
   |   |__clathrin-uncoating ATPase activity
   |   |__fatty acid ligase activity(+) 25 rec.
   |   |__helicase activity(+) 100 rec.
   |   |__membrane protein dislocase activity 4 rec.
   |   |__microfilament motor activity(+) 13 rec.
   |   |__microtubule motor activity(+) 44 rec.
   |   |__microtubule severing ATPase activity 6 rec.
   |   |__proteasome-activating activity 10 rec.
   |   |__tubulin-dependent ATPase activity
   |   |__ubiquitin-like modifier activating enzyme activity(+) 16 rec.
   |__binding 6300 rec.
   |   |__amine binding(+) 5 rec.
   |   |__amino acid binding(+) 6 rec.
   |   |__antigen binding(+) 4 rec.
   |   |__beta-endorphin binding
   |   |__carbohydrate binding(+) 126 rec.
   |   |__carbohydrate derivative binding(+) 1002 rec.
   |   |__catecholamine binding(+)
   |   |__cellulosome binding
   |   |__chromatin binding(+) 289 rec.
   |   |__cyclosporin A binding 11 rec.
   |   |__diazepam binding
   |   |__dibutyl phthalate binding 2 rec.
   |   |__diphenyl phthalate binding 2 rec.
   |   |__extracellular matrix binding(+) 6 rec.
   |   |__flavonoid binding(+)
   |   |__hormone binding(+) 16 rec.
   |   |__host cell surface binding(+)
   |   |__hydroquinone binding
   |   |__intermediate filament binding(+)
   |   |__kinetochore binding 1 rec.
   |   |__lipid binding(+) 216 rec.
   |   |__macrolide binding(+) 3 rec.
   |   |__melatonin binding
   |   |__modified amino acid binding(+) 14 rec.
   |   |__molybdopterin cofactor binding 2 rec.
   |   |__nucleic acid binding(+) 2443 rec.
   |   |__nucleoside phosphate binding(+) 955 rec.
   |   |__odorant binding(+) 112 rec.
   |   |__oligopeptide binding(+) 2 rec.
   |   |__peptide binding(+) 47 rec.
   |   |__pigment binding(+) 1 rec.
   |   |__polychlorinated biphenyl binding
   |   |__prosthetic group binding(+) 1 rec.
   |   |__protein binding(+) 2468 rec.
   |   |__protein-containing complex binding(+) 386 rec.
   |   |__resveratrol binding
   |   |__small molecule binding(+) 2186 rec.
   |   |__sulfur compound binding(+) 48 rec.
   |   |__synthetic cannabinoid binding
   |   |__tetrahydrobiopterin binding(+)
   |   |__tetrapyrrole binding(+) 134 rec.
   |   |__toxic substance binding 1 rec.
   |__cargo receptor activity 43 rec.
   |   |__alpha-2 macroglobulin receptor activity
   |   |__apolipoprotein receptor activity(+)
   |   |__asialoglycoprotein receptor activity
   |   |__COPII receptor activity 1 rec.
   |   |__ferritin receptor activity
   |   |__folic acid receptor activity
   |   |__glycoprotein cargo receptor activity
   |   |__heme receptor activity
   |   |__lactoferrin receptor activity
   |   |__lipoprotein particle receptor activity(+) 3 rec.
   |   |__scavenger receptor activity 20 rec.
   |   |__transferrin receptor activity
   |   |__vacuolar sorting signal receptor activity
   |   |__vitellogenin receptor activity 1 rec.
   |__catalytic activity 4653 rec.
   |   |__catalytic activity, acting on a nucleic acid(+) 523 rec.
   |   |__catalytic activity, acting on a protein(+) 1595 rec.
   |   |__cyclase activity(+) 33 rec.
   |   |__deacylase activity(+) 45 rec.
   |   |__demethylase activity(+) 18 rec.
   |   |__hydrolase activity(+) 1827 rec.
   |   |__isomerase activity(+) 304 rec.
   |   |__ligase activity(+) 191 rec.
   |   |__lyase activity(+) 165 rec.
   |   |__non-ribosomal peptide synthetase activity(+) 2 rec.
   |   |__oxidoreductase activity(+) 712 rec.
   |   |__peptidoglycan muralytic activity(+) 26 rec.
   |   |__polyketide synthase activity
   |   |__transferase activity(+) 1554 rec.
   |__cytoskeletal motor activity 57 rec.
   |   |__GTPase motor activity(+)
   |   |__microfilament motor activity(+) 13 rec.
   |   |__microtubule motor activity(+) 44 rec.
   |   |__proton motive force-driven motor activity
   |__dirigent protein activity
   |__electron transfer activity 56 rec.
   |   |__cytochrome bo3 ubiquinol oxidase activity
   |   |__cytochrome-c oxidase activity 7 rec.
   |   |__electron-transferring-flavoprotein dehydrogenase activity 1 rec.
   |   |__NADH dehydrogenase (ubiquinone) activity 24 rec.
   |   |__plastoquinol--plastocyanin reductase activity
   |   |__quinol-cytochrome-c reductase activity 8 rec.
   |__fusogenic activity 2 rec.
   |   |__GTPase-dependent fusogenic activity 2 rec.
   |__general transcription initiation factor activity 41 rec.
   |   |__mitochondrial RNA polymerase general transcription initiation factor activity
   |   |__RNA polymerase I general transcription initiation factor activity 1 rec.
   |   |__RNA polymerase II general transcription initiation factor activity 35 rec.
   |   |__RNA polymerase III general transcription initiation factor activity 6 rec.
   |__membrane bending activity 1 rec.
   |__membrane destabilizing activity
   |__membrane grommet activity
   |__molecular adaptor activity 959 rec.
   |   |__dbTF DNA binding stabilizer activity
   |   |__DNA-DNA tethering activity(+) 4 rec.
   |   |__membrane-membrane adaptor activity 2 rec.
   |   |__protein-macromolecule adaptor activity(+) 524 rec.
   |   |__triplet codon-amino acid adaptor activity(+) 381 rec.
   |__molecular carrier activity 87 rec.
   |   |__metallochaperone activity(+) 19 rec.
   |   |__nucleocytoplasmic carrier activity(+) 21 rec.
   |   |__oxygen carrier activity 1 rec.
   |   |__phosphopantetheine-dependent carrier activity(+) 1 rec.
   |   |__protein carrier chaperone(+) 40 rec.
   |   |__sulfur carrier activity 1 rec.
   |__molecular function regulator activity 774 rec.
   |   |__ATPase regulator activity(+) 35 rec.
   |   |__cytoskeletal motor regulator activity(+) 1 rec.
   |   |__enzyme regulator activity(+) 526 rec.
   |   |__G protein activity 3 rec.
   |   |__molecular function activator activity(+) 355 rec.
   |   |__molecular function inhibitor activity(+) 158 rec.
   |   |__molecular sensor activity(+) 33 rec.
   |   |__signaling receptor regulator activity(+) 142 rec.
   |   |__transporter regulator activity(+) 41 rec.
   |__molecular sequestering activity 24 rec.
   |   |__metal ion sequestering activity(+) 1 rec.
   |   |__protein sequestering activity(+) 16 rec.
   |   |__receptor decoy activity(+)
   |   |__RNA sequestering activity
   |   |__toxin sequestering activity
   |__molecular tag activity 21 rec.
   |   |__membrane tag activity
   |   |__protein tag activity 21 rec.
   |__molecular template activity 2 rec.
   |   |__DNA template activity(+)
   |   |__microtubule nucleator activity 2 rec.
   |__molecular transducer activity 493 rec.
   |   |__energy transducer activity(+)
   |   |__histidine phosphotransfer kinase activity
   |   |__phosphorelay response regulator activity
   |   |__signaling receptor activity(+) 493 rec.
   |__nutrient reservoir activity 6 rec.
   |__pore-forming activity 1 rec.
   |__protein folding chaperone 75 rec.
   |   |__ATP-dependent protein folding chaperone 38 rec.
   |__protein-containing complex destabilizing activity 8 rec.
   |   |__actin filament debranching activity
   |   |__actin filament severing activity
   |   |__ATP-dependent protein disaggregase activity 1 rec.
   |   |__microtubule destabilizing activity(+) 6 rec.
   |__protein-containing complex stabilizing activity 3 rec.
   |   |__microtubule stabilizing activity 2 rec.
   |__RNA folding chaperone 4 rec.
   |__structural molecule activity 764 rec.
   |   |__bioadhesive activity 8 rec.
   |   |__extracellular matrix structural constituent(+) 37 rec.
   |   |__structural constituent of albumen
   |   |__structural constituent of bone
   |   |__structural constituent of carboxysome shell
   |   |__structural constituent of cell wall(+)
   |   |__structural constituent of chromatin 121 rec.
   |   |__structural constituent of cutaneous appendage
   |   |__structural constituent of cuticle(+) 155 rec.
   |   |__structural constituent of cytoplasmic lattice
   |   |__structural constituent of cytoskeleton(+) 45 rec.
   |   |__structural constituent of egg chorion 13 rec.
   |   |__structural constituent of eye lens 4 rec.
   |   |__structural constituent of muscle 18 rec.
   |   |__structural constituent of myelin sheath
   |   |__structural constituent of nuclear lamina
   |   |__structural constituent of nuclear pore 23 rec.
   |   |__structural constituent of peritrophic membrane 2 rec.
   |   |__structural constituent of proteasome
   |   |__structural constituent of ribosome 300 rec.
   |   |__structural constituent of skin epidermis
   |   |__structural constituent of synapse(+) 4 rec.
   |   |__structural constituent of virion
   |   |__structural constituent of vitelline membrane 4 rec.
   |   |__structural molecule activity conferring elasticity(+) 2 rec.
   |__toxin activity
   |__transcription regulator activity 824 rec.
   |   |__anti-sigma factor antagonist activity
   |   |__DNA-binding transcription factor activity(+) 621 rec.
   |   |__mitochondrial transcription factor activity 2 rec.
   |   |__RNA-binding transcription regulator activity
   |   |__transcription antitermination factor activity, DNA binding
   |   |__transcription antitermination factor activity, RNA binding
   |   |__transcription coregulator activity(+) 206 rec.
   |   |__transcription elongation factor activity 6 rec.
   |__translation factor activity 82 rec.
   |   |__translation elongation factor activity 16 rec.
   |   |__translation factor activity, non-nucleic acid binding
   |   |__translation factor activity, RNA binding 6 rec.
   |   |__translation initiation factor activity(+) 53 rec.
   |   |__translation termination factor activity(+) 8 rec.
   |__translation regulator activity 36 rec.
   |   |__translation activator activity 5 rec.
   |   |__translation repressor activity(+) 28 rec.
   |__transporter activity 1262 rec.
       |__lipid transporter activity(+) 76 rec.
       |__paracellular tight junction channel activity
       |__protein transporter activity(+) 67 rec.
       |__transmembrane transporter activity(+) 1184 rec.
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