FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term MAP kinase kinase kinase activity ID (Ontology) GO:0004709 (Gene Ontology)
Definition Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.[ PubMed:9561267 ]
Also Known As "MAPK/ERK kinase kinase activity" ; "MEKK activity"
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       7
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 Gene Groups Genes
 MAP kinase kinase kinase activity (all annotations which use CV term, excluding "NOT" statements)       1      7
     enables | MAP kinase kinase kinase activity       --       7
Spanning Tree (Parents/Children)
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  protein kinase activity
   |__protein serine/threonine kinase activity
       |__MAP kinase kinase kinase activity  8 rec.
           |__JUN kinase kinase kinase activity 2 rec.
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Is a protein serine/threonine kinase activity
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Synonyms
  • "ATP:protein phosphotransferase (MAPKKKK-activated) activity" RELATED[ EC:2 ]
    "cMos" RELATED[ EC:2 ]
    "cRaf" RELATED[ EC:2 ]
    "MAP3K" RELATED[ EC:2 PubMed:20811974 ]
    "MAPK/ERK kinase kinase activity" EXACT
    "MAPKKK activity" RELATED[ EC:2 ]
    "MEK kinase activity" RELATED[ EC:2 ]
    "MEKK" RELATED[ EC:2 ]
    "MEKK activity" EXACT
    "MEKK1" RELATED[ EC:2 ]
    "MEKK2" RELATED[ EC:2 ]
    "MEKK3" RELATED[ EC:2 ]
    "Mil/Raf" RELATED[ EC:2 ]
    "mitogen-activated protein kinase kinase kinase activity" RELATED[ EC:2 ]
    "MLK-like mitogen-activated protein triple kinase activity" NARROW[ EC:2 ]
    "MLTK" RELATED[ EC:2 ]
    "MLTKa" RELATED[ EC:2 ]
    "MLTKb" RELATED[ EC:2 ]
    "REKS" RELATED[ EC:2 ]
    "STK28" RELATED[ EC:2 ]
Secondary IDs
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EC:2.7.11.25
MetaCyc:2.7.11.25-RXN
Reactome:R-HSA-2730887 "Autophosphorylation and activation of MEKK1"
Reactome:R-HSA-392530 "p-S400-Cot phosphorylates NIK"
Reactome:R-HSA-451649 "TPL2 phosphorylates MEK1, SEK1"
Reactome:R-HSA-727819 "TAK1 phosphorylates MKK6"
Reactome:R-HSA-933530 "Activation of IKK by MEKK1"