FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term protein tyrosine kinase activity ID (Ontology) GO:0004713 (Gene Ontology)
Definition Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
Also Known As "protein-tyrosine kinase activity"
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      28
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 protein tyrosine kinase activity (all annotations which use CV term, excluding "NOT" statements)       1     28
     enables | protein tyrosine kinase activity       --      28
 NOT | enables | protein tyrosine kinase activity       --       2
Spanning Tree (Parents/Children)
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kinase activity_________________________________________
phosphotransferase activity, alcohol group as acceptor__|
catalytic activity, acting on a protein_________________|
                                                        protein kinase activity
                                                         |__protein tyrosine kinase activity  33 rec.
                                                             |__histone H2AXY142 kinase activity
                                                             |__histone H3Y41 kinase activity
                                                             |__non-membrane spanning protein tyrosine kinase activity 13 rec.
                                                             |__transmembrane receptor protein tyrosine kinase activity 18 rec.
                                                                 |__boss receptor activity 1 rec.
                                                                 |__brain-derived neurotrophic factor receptor activity
                                                                 |__ephrin receptor activity(+) 1 rec.
                                                                 |__epidermal growth factor receptor activity 1 rec.
                                                                 |__fibroblast growth factor receptor activity 2 rec.
                                                                 |__hepatocyte growth factor receptor activity
                                                                 |__insulin receptor activity 1 rec.
                                                                 |__insulin-like growth factor receptor activity
                                                                 |__macrophage colony-stimulating factor receptor activity
                                                                 |__placental growth factor receptor activity
                                                                 |__platelet-derived growth factor receptor activity(+)
                                                                 |__protein tyrosine kinase collagen receptor activity 1 rec.
                                                                 |__stem cell factor receptor activity
                                                                 |__vascular endothelial growth factor receptor activity
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Synonyms
  • "protein-tyrosine kinase activity" EXACT
Secondary IDs
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EC:2.7.10.-
MetaCyc:2.7.10.1-RXN
Reactome:R-HSA-112333 "SRC autophosphorylation is positively regulated by InlA-bound CDH1"
Reactome:R-HSA-114600 "Fyn/Lyn-mediated phosphorylation of FcR1 gamma"
Reactome:R-HSA-1168394 "STAT5 tyrosine phosphorylation"
Reactome:R-HSA-1169421 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers"
Reactome:R-HSA-1225952 "Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants"
Reactome:R-HSA-1225960 "Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants"
Reactome:R-HSA-1247844 "Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants"
Reactome:R-HSA-1248655 "Trans-autophosphorylation of EGFRvIII mutant dimers"
Reactome:R-HSA-1248694 "Trans-autophosphorylation of ERBB2 homodimer"
Reactome:R-HSA-1250195 "SHC1 phosphorylation by ERBB2 heterodimers"
Reactome:R-HSA-1250315 "Trans-autophosphorylation of ERBB4 homodimers"
Reactome:R-HSA-1250348 "Phosphorylation of SHC1 by ERBB4 homodimers"
Reactome:R-HSA-1251922 "PLCG1 phosphorylation by p-EGFR:p-ERBB2"
Reactome:R-HSA-1295540 "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5"
Reactome:R-HSA-1295609 "SRC phosphorylates SPRY2 on Y55 and Y227"
Reactome:R-HSA-1307963 "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4"
Reactome:R-HSA-1433418 "Phosphorylation of JAK2"
Reactome:R-HSA-1433454 "Phosphorylation of GAB2 by SFKs"
Reactome:R-HSA-1433488 "Phosphorylation of SHP2 by SFKs"
Reactome:R-HSA-1433506 "Phosphorylation of APS"
Reactome:R-HSA-1433542 "Phosphorylation and activation of VAV1"
Reactome:R-HSA-1470009 "Phosphorylation of STATs"
Reactome:R-HSA-1472121 "Phosphorylation of p-KIT on Y900 by Src kinases"
Reactome:R-HSA-1524186 "Phosphorylation of PLCgamma by PDGFR"
Reactome:R-HSA-1671691 "PRLR-bound STAT5 is phosphorylated"
Reactome:R-HSA-170070 "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes"
Reactome:R-HSA-170156 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes"
Reactome:R-HSA-170991 "SRC-1 autophosphorylates"
Reactome:R-HSA-171011 "Binding and activation of MAP Kinase"
Reactome:R-HSA-174164 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15"
Reactome:R-HSA-177934 "EGFR autophosphorylation"
Reactome:R-HSA-177937 "Phosphorylation of EGFR by SRC kinase"
Reactome:R-HSA-182969 "Phosphorylation of CBL (EGFR:CBL)"
Reactome:R-HSA-183058 "Phosphorylation of CBL (EGFR:GRB2:CBL)"
Reactome:R-HSA-1839065 "Phosphorylation of cytosolic FGFR1 fusion dimers"
Reactome:R-HSA-1839067 "Phosphorylation of BCR moiety of BCR-FGFR1"
Reactome:R-HSA-1839098 "Activated FGFR1 mutants and fusions phosphorylate PLCG1"
Reactome:R-HSA-1839110 "p-BCR-p-FGFR1 phosphorylates GAB2"
Reactome:R-HSA-1839112 "Phosphorylation of STAT5 by cytosolic FGFR1 fusions"
Reactome:R-HSA-186786 "Autophosphorylation of PDGF beta receptors"
Reactome:R-HSA-1888198 "FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3"
Reactome:R-HSA-190326 "Autocatalytic phosphorylation of FGFR4"
Reactome:R-HSA-190385 "Autocatalytic phosphorylation of FGFR3b"
Reactome:R-HSA-190388 "Autocatalytic phosphorylation of FGFR3c"
Reactome:R-HSA-190408 "Autocatalytic phosphorylation of FGFR2b"
Reactome:R-HSA-190413 "Autocatalytic phosphorylation of FGFR2c"
Reactome:R-HSA-190427 "Autocatalytic phosphorylation of FGFR1b"
Reactome:R-HSA-190429 "Autocatalytic phosphorylation of FGFR1c"
Reactome:R-HSA-191062 "Autocatalytic phosphorylation of Klotho-bound FGFR1c"
Reactome:R-HSA-191636 "Phosphorylation of Cx43 by c-src"
Reactome:R-HSA-1963581 "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers"
Reactome:R-HSA-1963582 "Trans-autophosphorylation of ERBB2 heterodimers"
Reactome:R-HSA-1963586 "SRC family kinases phosphorylate ERBB2"
Reactome:R-HSA-1982066 "Ligand-independent phosphorylation of overexpressed FGFR1"
Reactome:R-HSA-2012073 "Autocatalytic phosphorylation of FGFR3c P250R mutant"
Reactome:R-HSA-2012082 "Autocatalytic phosphorylation of FGFR3 cysteine mutants"
Reactome:R-HSA-2012087 "Autocatalytic phosphorylation of FGFR4 Y367C mutant"
Reactome:R-HSA-201521 "ALK autophosphorylation"
Reactome:R-HSA-202165 "Phosphorylation of ITAM motifs in CD3 complexes"
Reactome:R-HSA-202168 "Phosphorylation of ZAP-70 by Lck"
Reactome:R-HSA-202174 "Activation of ZAP-70"
Reactome:R-HSA-202216 "Phosphorylation of SLP-76"
Reactome:R-HSA-202233 "Inactivation of Lck by Csk"
Reactome:R-HSA-202245 "Phosphorylation of TBSMs in LAT"
Reactome:R-HSA-202248 "Phosphorylation of PLC-gamma1"
Reactome:R-HSA-202291 "Activation of Lck"
Reactome:R-HSA-202307 "Change of PKC theta conformation"
Reactome:R-HSA-2023455 "Autocatalytic phosphorylation of FGFR1c P252X mutant dimers"
Reactome:R-HSA-2023460 "Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity"
Reactome:R-HSA-2029268 "Phosphorylation and activation of PLCG"
Reactome:R-HSA-2029449 "Phosphorylation of SYK by Src kinases"
Reactome:R-HSA-2029453 "Phosphorylation of VAV"
Reactome:R-HSA-2029459 "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts"
Reactome:R-HSA-2029984 "Autocatalytic phosphorylation of FGFR2 ligand-independent mutants"
Reactome:R-HSA-2029989 "Autocatalytic phosphorylation of overexpressed FGFR2 variants"
Reactome:R-HSA-2033485 "Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity"
Reactome:R-HSA-2033486 "Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding"
Reactome:R-HSA-2033488 "Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding"
Reactome:R-HSA-2033490 "Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity"
Reactome:R-HSA-2038387 "Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants"
Reactome:R-HSA-2038944 "Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity"
Reactome:R-HSA-205289 "Autophosphorylation of KIT"
Reactome:R-HSA-210291 "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src"
Reactome:R-HSA-210872 "Trans-phosphorylation of Tie2"
Reactome:R-HSA-212710 "EGFR activates PLC-gamma1 by phosphorylation"
Reactome:R-HSA-2130194 "ABL phosphorylates WAVEs"
Reactome:R-HSA-2197698 "Src phosphorylate WASP,N-WASP"
Reactome:R-HSA-2201322 "TIRAP is phosphorylated by BTK"
Reactome:R-HSA-2395412 "Phosphorylation of SYK"
Reactome:R-HSA-2395439 "Phosphorylation of DAP12"
Reactome:R-HSA-2395801 "Phosphorylation of LAT by p-SYK"
Reactome:R-HSA-2396594 "Phosphorylation of SLP-76 by p-SYK"
Reactome:R-HSA-2404193 "IGF1R phosphorylates SHC1"
Reactome:R-HSA-2404199 "IGF1,2:IGF1R autophosphorylates"
Reactome:R-HSA-2424484 "Phosphorylation of BTK by p-SYK"
Reactome:R-HSA-2424486 "Phosphorylation and activation of VAV2/VAV3 by SYK"
Reactome:R-HSA-2424487 "Phosphorylation of PLC-gamma by p-BTK/p-SYK"
Reactome:R-HSA-2428926 "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4"
Reactome:R-HSA-2454208 "Phosphorylation of beta and gamma subunits by LYN"
Reactome:R-HSA-2454239 "Phosphorylation of SYK"
Reactome:R-HSA-2586553 "JAK2 Phosphorylates LEPR"
Reactome:R-HSA-2586555 "JAK2 Autophosphorylates in Response to Leptin"
Reactome:R-HSA-2671742 "JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin"
Reactome:R-HSA-2671829 "JAK2 Phosphorylates STAT5 in Response to Leptin"
Reactome:R-HSA-2671850 "JAK2 Phosphoryates STAT3 in Response to Leptin"
Reactome:R-HSA-2730833 "Phosphorylation of TEC kinases by p-SYK"
Reactome:R-HSA-2730843 "Phosphorylation of LAT by p-SYK"
Reactome:R-HSA-2730851 "Phosphorylation of SLP-76 by p-SYK"
Reactome:R-HSA-2730858 "Autophosphorylation of BTK/ITK"
Reactome:R-HSA-2730860 "Phosphorylation of GAB2 by SYK/FYN"
Reactome:R-HSA-2730862 "Autophosphorylation of LYN kinase"
Reactome:R-HSA-2730882 "Phosphorylation of PKC-theta"
Reactome:R-HSA-2730884 "Phosphorylation of NTAL by p-SYK/Lyn"
Reactome:R-HSA-2730886 "Phosphorylation of SHC by SYK kinase"
Reactome:R-HSA-2730888 "Phosphorylation of PLC-gamma"
Reactome:R-HSA-3215391 "PRMT5 is tyrosine phosphorylated by JAK2 V617F"
Reactome:R-HSA-354073 "Autophosphorylation of PTK2 at Y397"
Reactome:R-HSA-354124 "Phosphorylation of pPTK2 by SRC"
Reactome:R-HSA-372693 "Phosphorylation of BCAR1 by SRC-PTK2 complex"
Reactome:R-HSA-373747 "Phosphorylation of nephrin by FYN"
Reactome:R-HSA-373750 "SEMA4D interacts with Plexin-B1:ErbB2"
Reactome:R-HSA-374701 "Phosphorylation of DCC by Fyn"
Reactome:R-HSA-377640 "Autophosphorylation of SRC"
Reactome:R-HSA-380780 "Activation of Src"
Reactome:R-HSA-388831 "Phosphorylation of CD28"
Reactome:R-HSA-388833 "Phosphorylation of CTLA-4"
Reactome:R-HSA-389083 "Autophosphorylation of PDGF alpha receptors"
Reactome:R-HSA-389086 "Autophosphorylation of PDGF alpha/beta receptors"
Reactome:R-HSA-389159 "CSF1R trans-autophosphorylates on multiple tyrosine and serine residues"
Reactome:R-HSA-389354 "Activation of Vav1"
Reactome:R-HSA-389762 "Phosphorylation of PD-1"
Reactome:R-HSA-391156 "Phosphorylation of ITIM motif in SIRP alpha"
Reactome:R-HSA-391865 "Recruitment of FAK to NCAM1:Fyn in lipid rafts"
Reactome:R-HSA-391866 "Phosphorylation of FAK by Src kinase"
Reactome:R-HSA-391871 "Autophosphorylation of NCAM1 bound Fyn"
Reactome:R-HSA-3928578 "EPH receptors autophosphorylate"
Reactome:R-HSA-3928580 "SFKs phosphorylate EFNBs"
Reactome:R-HSA-3928583 "FYN phosphorylates NMDAR2B"
Reactome:R-HSA-3928594 "SFKs phosphorylate GIT1"
Reactome:R-HSA-3928604 "SFKs phosphorylate VAV2,3"
Reactome:R-HSA-3928610 "PTK2 autophosphorylates at Y397"
Reactome:R-HSA-3928627 "EPHB phosphorylates TIAM1"
Reactome:R-HSA-3928648 "SFKs phosphorylate NGEF"
Reactome:R-HSA-399934 "Phosphorylation of Plexin-A"
Reactome:R-HSA-399946 "Recruitment and activation of Cdk5"
Reactome:R-HSA-399947 "Tyrosine phosphorylation of CRMPs by Fes"
Reactome:R-HSA-4093332 "p-EPHB phosphorylates SDC2"
Reactome:R-HSA-418163 "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)"
Reactome:R-HSA-418859 "Phosphorylation of Unc5C"
Reactome:R-HSA-418872 "Phosphorylation of FADK1"
Reactome:R-HSA-419646 "SEMA4D interacts with Plexin-B1:Met"
Reactome:R-HSA-428888 "Phosphorylation of ROBO1 by ABL kinase"
Reactome:R-HSA-429441 "SYK activation by SRC"
Reactome:R-HSA-429449 "Syk activation leads to SLP-76 activation"
Reactome:R-HSA-432129 "FGR binds and phosphorylates LRP8"
Reactome:R-HSA-434836 "Syk/Lck phosphorylate LAT"
Reactome:R-HSA-4420117 "VEGFR2 autophosphorylates"
Reactome:R-HSA-4420121 "SFKs phosphorylate PLCG1"
Reactome:R-HSA-4420128 "SRC-1 phosphorylates SHB"
Reactome:R-HSA-4420206 "Phosphorylation of SRC-1"
Reactome:R-HSA-443817 "Phosphorylation of L1 by EPHB2"
Reactome:R-HSA-445076 "Phosphorylation of Y1229 in L1"
Reactome:R-HSA-445084 "Phosphorylation of L1 by SRC"
Reactome:R-HSA-445085 "Phosphorylation of VAV2"
Reactome:R-HSA-445091 "Phosphorylation of Neurofascin"
Reactome:R-HSA-451942 "Within the IL-2R complex JAK3 phosphorylates JAK1"
Reactome:R-HSA-452097 "Recruited STAT5 is phosphorylated"
Reactome:R-HSA-452100 "SHC1 bound to IL2 receptor is phosphorylated"
Reactome:R-HSA-452122 "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB"
Reactome:R-HSA-508282 "SYK is a substrate for JAK1"
Reactome:R-HSA-5218640 "SRC-1 phosphorylates p-Y397-PTK2"
Reactome:R-HSA-5218642 "PTK2 autophosphorylates"
Reactome:R-HSA-5218806 "FYN autophosphorylates"
Reactome:R-HSA-5218809 "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118"
Reactome:R-HSA-5218812 "FYN phosphorylates PAK2"
Reactome:R-HSA-5218820 "Src kinases phosphorylate VAV"
Reactome:R-HSA-5218828 "PTK2/SRC-1 phosphorylates BCAR1"
Reactome:R-HSA-5218830 "SRC-1 phosphorylates PTK2-beta"
Reactome:R-HSA-5218851 "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407"
Reactome:R-HSA-5357429 "AXL autophosphorylates on Y779 and Y821"
Reactome:R-HSA-5607745 "1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG"
Reactome:R-HSA-5607750 "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan"
Reactome:R-HSA-5621355 "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG"
Reactome:R-HSA-5621363 "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2"
Reactome:R-HSA-5621370 "SYK autophosphorylates"
Reactome:R-HSA-5624486 "SFKs phosphorylates RAF1 on Y340,Y341"
Reactome:R-HSA-5637795 "Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant"
Reactome:R-HSA-5637796 "Phosphorylation of SHC1 by p-5Y-EGFRvIII"
Reactome:R-HSA-5654147 "Activated FGFR2 phosphorylates PLCG1"
Reactome:R-HSA-5654149 "Activated FGFR1 phosphorylates PLCG1"
Reactome:R-HSA-5654151 "Activated FGFR4 phosphorylates PLCG1"
Reactome:R-HSA-5654222 "Activated FGFR3 phosphorylates PLCG1"
Reactome:R-HSA-5654397 "Activated FGFR2 phosphorylates FRS2"
Reactome:R-HSA-5654407 "Activated FGFR2 phosphorylates SHC1"
Reactome:R-HSA-5654408 "Activated FGFR3 phosphorylates FRS2"
Reactome:R-HSA-5654418 "Activated FGFR4 phosphorylates FRS2"
Reactome:R-HSA-5654428 "Activated FGFR4 phosphorylates SHC1"
Reactome:R-HSA-5654545 "Ligand-independent phosphorylation of overexpressed FGFR1c"
Reactome:R-HSA-5654575 "Activated FGFR1 phosphorylates FRS2"
Reactome:R-HSA-5654578 "Activated FGFR1 phosphorylates FRS3"
Reactome:R-HSA-5654582 "Activated FGFR1 phosphorylates SHC1"
Reactome:R-HSA-5654587 "Activated FGFR1:p-FRS phosphorylates PPTN11"
Reactome:R-HSA-5654605 "Activated FGFR2 phosphorylates FRS3"
Reactome:R-HSA-5654607 "Activated FGFR2 phosphorylates PPTN11"
Reactome:R-HSA-5654628 "Activated FGFR3 phosphorylates FRS3"
Reactome:R-HSA-5654631 "Activated FGFR3 phosphorylates PPTN11"
Reactome:R-HSA-5654634 "Activated FGFR3 phosphorylates SHC1"
Reactome:R-HSA-5654653 "Activated FGFR4 phosphorylates FRS3"
Reactome:R-HSA-5654655 "Activated FGFR4 phosphorylates PPTN11"
Reactome:R-HSA-5655243 "Activated FGFR3 point and translocation mutants phosphorylate PLCG1"
Reactome:R-HSA-5655268 "Activated FGFR2 mutants phosphorylate FRS2"
Reactome:R-HSA-5655270 "Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2"
Reactome:R-HSA-5655278 "Activated FGFR1 mutants phosphorylate FRS2"
Reactome:R-HSA-5655284 "Activated FGFR4 mutants phosphorylate FRS2"
Reactome:R-HSA-5655301 "Activated FGFR2 mutants phosphorylate PLCG1"
Reactome:R-HSA-5655341 "Activated FGFR4 mutants phosphorylate PLCG1"
Reactome:R-HSA-5683930 "WICH phosphorylates H2AFX on Y142"
Reactome:R-HSA-5686587 "ABL1 phosphorylates RAD52"
Reactome:R-HSA-5690702 "LYN phosphorylates CD22"
Reactome:R-HSA-6784006 "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2"
Reactome:R-HSA-6784319 "JAK1,TYK2 phosphorylate JAK1,TYK2"
Reactome:R-HSA-6790087 "HVEM induses BTLA phosphorylation"
Reactome:R-HSA-6806974 "MET dimers autophosphorylate"
Reactome:R-HSA-68954 "Mcm2-7 is phosphorylated by DDK"
Reactome:R-HSA-69195 "Phosphorylation of Cyclin E:CDK2 complexes by WEE1"
Reactome:R-HSA-873918 "Transphosphorylation of JAK1"
Reactome:R-HSA-873919 "Phosphorylation of JAK2"
Reactome:R-HSA-873922 "Phosphorylation of STAT1 by JAK kinases"
Reactome:R-HSA-873924 "Phosphorylation of IFNGR1 by JAK kinases"
Reactome:R-HSA-879907 "Tyrosine kinases phosphorylate the receptor"
Reactome:R-HSA-879909 "Activation of STAT5a/b by JAK2"
Reactome:R-HSA-879925 "SHC1 bound to the common beta chain becomes tyrosine phosphorylated"
Reactome:R-HSA-8847977 "FRK phosphorylates PTEN"
Reactome:R-HSA-8848005 "ERBB2 promotes PTK6 autophosphorylation"
Reactome:R-HSA-8848077 "PTK6 phosphorylates STAP2"
Reactome:R-HSA-8848124 "PTK6 phosphorylates STAT3"
Reactome:R-HSA-8848436 "PTK6 phosphorylates CDKN1B"
Reactome:R-HSA-8848606 "PTK6 phosphorylates PXN"
Reactome:R-HSA-8848726 "PTK6 phosphorylates BCAR1"
Reactome:R-HSA-8848758 "PTK6 phosphorylates AKT1"
Reactome:R-HSA-8848776 "PTK6 phosphorylates DOK1"
Reactome:R-HSA-8848818 "PTK6 phosphorylates CBL"
Reactome:R-HSA-8848873 "PTK6 phosphorylates ARAP1"
Reactome:R-HSA-8848975 "PTK6 phosphorylates KHDRBS1"
Reactome:R-HSA-8849032 "PTK6 phosphorylates KHDRBS2"
Reactome:R-HSA-8849042 "PTK6 phosphorylates KHDRBS3"
Reactome:R-HSA-8849068 "PTK6 phosphorylates ARHGAP35"
Reactome:R-HSA-8849102 "SRMS phosphorylates PTK6"
Reactome:R-HSA-8849463 "PTK6 phosphorylates SFPQ"
Reactome:R-HSA-8851890 "MET phosphorylates SHC1-2"
Reactome:R-HSA-8851933 "MET phosphorylates GAB1"
Reactome:R-HSA-8853309 "Autocatalytic phosphorylation of FGFR3 fusions"
Reactome:R-HSA-8853313 "FGFR2 fusions autophosphorylate"
Reactome:R-HSA-8853325 "Plasma membrane FGFR1 fusions autophosphorylate"
Reactome:R-HSA-8855237 "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1"
Reactome:R-HSA-8857555 "EGFR phosphorylates GPNMB"
Reactome:R-HSA-8857577 "LINC01139 facilitates PTK6 autophosphorylation"
Reactome:R-HSA-8857583 "LINC01139 promotes phosphorylation of HIF1A by PTK6"
Reactome:R-HSA-8857925 "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307"
Reactome:R-HSA-8867041 "EGFR phosphorylates EPS15"
Reactome:R-HSA-8874078 "PTK2 autophosphorylates"
Reactome:R-HSA-8874080 "SRC phosphorylates PTK2"
Reactome:R-HSA-8874082 "MET phosphorylates PTK2"
Reactome:R-HSA-8875451 "MET phosphorylates CBL"
Reactome:R-HSA-8875817 "MET phosphorylates STAT3"
Reactome:R-HSA-8876230 "InlB:MET dimer trans-autophophorylates"
Reactome:R-HSA-8876246 "InlB-activated MET phosphorylates CBL"
Reactome:R-HSA-8876948 "SRC phosphorylates InlA-bound CDH1 and CTNNB1"
Reactome:R-HSA-8937728 "SRC phosphorylates RUNX1"
Reactome:R-HSA-8937807 "SRC phosphorylates RUNX3"
Reactome:R-HSA-8937844 "SRC,YES1 phosphorylate YAP1"
Reactome:R-HSA-8942607 "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes"
Reactome:R-HSA-8948143 "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18"
Reactome:R-HSA-8956659 "ABL1 phosphorylates YAP1"
Reactome:R-HSA-8964242 "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC"
Reactome:R-HSA-8964252 "G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC"
Reactome:R-HSA-8983872 "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4"
Reactome:R-HSA-9006323 "Phospho-JAK2 phosphorylates EPOR"
Reactome:R-HSA-9006332 "JAK2 transphosphorylates and is activated in response to Erythropoietin"
Reactome:R-HSA-9011241 "SRC phosphorylates ROBO3.1 in response to NTN1"
Reactome:R-HSA-9012650 "JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2"
Reactome:R-HSA-9018572 "EGFR phosphorylates NOTCH3"
Reactome:R-HSA-9021609 "ESR-associated SRC autophosphorylates"
Reactome:R-HSA-9024726 "LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1"
Reactome:R-HSA-9026464 "BDNF-bound NTRK2 dimers trans-autophosphorylate"
Reactome:R-HSA-9026502 "NTF3-bound NTRK2 dimers trans-autophosphorylate"
Reactome:R-HSA-9026510 "NTF4-bound NTRK2 dimers trans-autophosphorylate"
Reactome:R-HSA-9026579 "NTRK2 phosphorylates PLCG1"
Reactome:R-HSA-9026890 "NTRK2 phosphorylates SHC1"
Reactome:R-HSA-9027272 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2"
Reactome:R-HSA-9027273 "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1"
Reactome:R-HSA-9027425 "LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2"
Reactome:R-HSA-9028728 "NTRK2 phosphorylates FRS2"
Reactome:R-HSA-9029151 "JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1"
Reactome:R-HSA-9029155 "JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1"
Reactome:R-HSA-9032426 "NTRK2 phosphorylates FRS3"
Reactome:R-HSA-9032532 "NTRK2-bound FYN autophosphorylates"
Reactome:R-HSA-9032601 "FYN-mediated phosphorylation of GRIN2B"
Reactome:R-HSA-9032854 "NTRK2 phosphorylates CDK5"
Reactome:R-HSA-9033284 "NTRK2 promotes TIAM1 phosphorylation"
Reactome:R-HSA-9034714 "NTRK3 dimers trans-autophosphorylate"
Reactome:R-HSA-9034814 "NTRK3 phosphorylates PLCG1"
Reactome:R-HSA-9034875 "NTRK3 phosphorylates SHC1"
Reactome:R-HSA-9037040 "SRC,FYN phosphorylate NTRK2"
Reactome:R-HSA-909718 "Formation of p-STAT1 homodimer"
Reactome:R-HSA-909726 "Phosphorylation of STAT1"
Reactome:R-HSA-909729 "Activation of JAK kinases"
Reactome:R-HSA-909730 "Phosphorylation of INFAR1 by TYK2"
Reactome:R-HSA-909732 "Phosphorylation of STAT2"
Reactome:R-HSA-912629 "CBL is tyrosine phosphorylated"
Reactome:R-HSA-9603420 "Activated NTRK3 promotes SRC autophosphorylation"
Reactome:R-HSA-9604767 "FLT3LG dimer:FLT3 dimer autophosphorylates"
Reactome:R-HSA-9606159 "BTK autophosphorylates"
Reactome:R-HSA-9606162 "Phosphorylated BTK phosphorylates PLCG2"
Reactome:R-HSA-9606163 "p-SYK and LYN phosphorylate BTK"
Reactome:R-HSA-9612085 "SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs"
Reactome:R-HSA-9612996 "NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates"
Reactome:R-HSA-9613023 "NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates"
Reactome:R-HSA-9624014 "SHC1 is phosphorylated downstream of estrogen stimulation of GPER1"
Reactome:R-HSA-9625487 "PTK2 autophosphorylates downstream of EGFR"
Reactome:R-HSA-9634390 "ERBB2 homodimer phosphorylates SHC1"
Reactome:R-HSA-9664261 "Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK"
Reactome:R-HSA-9664275 "Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers"
Reactome:R-HSA-9664278 "Phosphorylation and activation of PLCG due to FCGR3A effect"
Reactome:R-HSA-9664588 "ERBB2 KD mutants trans-autophosphorylate"
Reactome:R-HSA-9664976 "Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1"
Reactome:R-HSA-9665032 "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1"
Reactome:R-HSA-9665389 "Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate"
Reactome:R-HSA-9665411 "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1"
Reactome:R-HSA-9665704 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1"
Reactome:R-HSA-9665705 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1"
Reactome:R-HSA-9665709 "ERBB2 TMD/JMD heterodimers trans-autophosphorylate"
Reactome:R-HSA-9666425 "p-6Y-SYK phosphorylates VAV1,2,3"
Reactome:R-HSA-9669890 "Constitutive phosphorylation of kinase domain KIT mutants"
Reactome:R-HSA-9669911 "Phosphorylation of juxtamembrane domain KIT mutants"
Reactome:R-HSA-9670412 "Phosphorylation of STATs downstream of KIT mutants"
Reactome:R-HSA-9670418 "Phosphorylation of JAK2 downstream of KIT mutants"
Reactome:R-HSA-9672173 "Autophosphorylation of PDGFRA extracellular domain dimers"
Reactome:R-HSA-9672175 "Autophosphorylation of PDGFR mutant dimers"
Reactome:R-HSA-9673756 "Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins"
Reactome:R-HSA-9673761 "Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB"
Reactome:R-HSA-9674558 "p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1"
Reactome:R-HSA-9674567 "p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2"
Reactome:R-HSA-9680248 "Phosphorylation of extracellular domain KIT mutants"
Reactome:R-HSA-9695834 "Constitutive phosphorylation of FLT3 mutants"
Reactome:R-HSA-9698003 "FLT3 mutants phosphorylate GAB2"
Reactome:R-HSA-9698005 "FLT3 ITD mutants phosphorylate STAT5"
Reactome:R-HSA-9699578 "Active FLT3 phosphorylates CDKN1B"
Reactome:R-HSA-9700164 "Active ALK phosphorylates FRS2"
Reactome:R-HSA-9700168 "Active ALK phosphorylates IRS1"
Reactome:R-HSA-9700171 "Active ALK phosphorylates PLCG1"
Reactome:R-HSA-9700175 "Active ALK phosphorylates SHC1"
Reactome:R-HSA-9700181 "Autophosphorylation of ALK fusions"
Reactome:R-HSA-9700186 "Autophosphorylation of point mutants of ALK"
Reactome:R-HSA-9700193 "ALK mutants phosphorylate SHC1"
Reactome:R-HSA-9700647 "Active ALK phosphorylates SRC"
Reactome:R-HSA-9701488 "Active ALK phosphorylates JAK3"
Reactome:R-HSA-9703437 "FLT3 fusion dimers autophosphorylate"
Reactome:R-HSA-9703438 "FLT3 fusions phosphorylate GAB2"
Reactome:R-HSA-9706344 "FLT3 phosphorylates GRB10"
Reactome:R-HSA-9706350 "FLT3 phosphorylates CBL"
Reactome:R-HSA-9709918 "PTK6 phosphorylates STAT3"
Reactome:R-HSA-9712082 "ALK fusions phosphorylate IRS1"
Reactome:R-HSA-9712085 "ALK mutants phosphorylate STAT3"
Reactome:R-HSA-9712086 "ALK fusions phosphorylate PLCG1"
Reactome:R-HSA-9712087 "ALK fusions phosphorylate FRS"
Reactome:R-HSA-9726848 "SRC phosphorylates RHOU"
Reactome:R-HSA-9732738 "JAK1-mediated phosphorylation of RAF1"
Reactome:R-HSA-9733314 "CSF1R trans-autophosphorylates on tyrosine-561"
Reactome:R-HSA-9733323 "Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL"
Reactome:R-HSA-9762209 "BACH1 is phosphorylated at tyrosine 483"
Reactome:R-HSA-982807 "JAK2 phosphorylation of GHR"
Reactome:R-HSA-9831136 "SH pentamer is phosphorylated"
Reactome:R-HSA-983703 "p-6Y-SYK phosphorylates BLNK (SLP65)"
Reactome:R-HSA-983707 "SYK autophosphorylates at the activated BCR"
Reactome:R-HSA-983709 "LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)"
Reactome:R-HSA-9841924 "ABL1 phosphorylates PPARG2"
Reactome:R-HSA-9842648 "Autophosphorylation of LTK dimer:ALKAL1,2"
Reactome:R-HSA-9842651 "Active LTK receptor phosphorylates SHC1"
Reactome:R-HSA-9842666 "Active LTK phosphorylates IRS1"
Reactome:R-HSA-9842667 "CLIP1-LTK fusion autophosphorylates"
Reactome:R-HSA-9860500 "Phosphorylation of KDR (VEGFR2) and FLT4 (VEGFR3) and PECAM1 in PECAM1:CDH5:KDR:FLT4:CTNNB1"
Reactome:R-HSA-9860759 "p-T816-PKN2 phosphorylates AKT1 on serine-308"
Reactome:R-HSA-9861469 "p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA)"
Reactome:R-HSA-9865196 "p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1"
RHEA:10596