FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term non-membrane spanning protein tyrosine kinase activity ID (Ontology) GO:0004715 (Gene Ontology)
Definition Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.[ EC:2 ]
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      12
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 Gene Groups Genes
 non-membrane spanning protein tyrosine kinase activity (all annotations which use CV term, excluding "NOT" statements)       1     12
     enables | non-membrane spanning protein tyrosine kinase activity       --      12
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  protein kinase activity
   |__protein tyrosine kinase activity
       |__non-membrane spanning protein tyrosine kinase activity  13 rec.
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Is a protein tyrosine kinase activity
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Synonyms
  • "ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" RELATED[ EC:2 ]
    "ATP:protein-tyrosine O-phosphotransferase activity" BROAD[ EC:2 ]
    "Bruton's tyrosine kinase activity" NARROW[ EC:2 ]
    "cytoplasmic protein tyrosine kinase activity" NARROW[ EC:2 ]
    "focal adhesion kinase activity" NARROW[ EC:2 ]
    "janus kinase 1 activity" NARROW[ EC:2 ]
    "janus kinase 2 activity" NARROW[ EC:2 ]
    "janus kinase 3 activity" NARROW[ EC:2 ]
    "non-specific protein-tyrosine kinase activity" RELATED[ EC:2 ]
    "p60c-src protein tyrosine kinase activity" NARROW[ EC:2 ]
Secondary IDs
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EC:2.7.10.2
Reactome:R-HSA-1112602 "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor"
Reactome:R-HSA-1112703 "PTPN11 is phosphorylated"
Reactome:R-HSA-1168423 "JAK2 phosphorylation of IRS-1/2"
Reactome:R-HSA-1168459 "Lyn activates ERK"
Reactome:R-HSA-1168767 "JAK2 phosphorylates STAT1/STAT3"
Reactome:R-HSA-1295519 "IL7R is phosphorylated on Y499"
Reactome:R-HSA-1369115 "SHP2 is phosphorylated"
Reactome:R-HSA-432148 "Fgr may phosphorylate p38 MAPK"
Reactome:R-HSA-437936 "p-Y348-SYK phosphorylates VAV family"
Reactome:R-HSA-453200 "SYK autophosphorylates"
Reactome:R-HSA-6786095 "JAK1 phosphorylates STAT3,STAT6"
Reactome:R-HSA-6786096 "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated"
Reactome:R-HSA-6788582 "STAT1,STAT3,STAT6 phosphorylation"
Reactome:R-HSA-879910 "JAK2 is phosphorylated, activated"
Reactome:R-HSA-8871373 "BMX phosphorylates RUFY1"