FB2026_02 , released June 18, 2026

CV Term Report

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General Information

Term

signal recognition particle, endoplasmic reticulum targeting

ID (Ontology)

GO:0005786 (Gene Ontology)

Definition

A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana.[ ISBN:0198506732 ]

Also Known As

"signal sequence receptor complex" ; "SRP"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_CELLULAR_COMPONENT

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
signal recognition particle, endoplasmic reticulum targeting (all annotations which use CV term, excluding "NOT" statements)
part_of \| signal recognition particle, endoplasmic reticulum targeting	--

Spanning Tree (Parents/Children)

cytoplasm__________________
ribonucleoprotein complex__|
                           signal recognition particle
                            |__signal recognition particle, endoplasmic reticulum targeting  9 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	signal recognition particle
Part of
Synonyms & Secondary IDs
Synonyms
	"signal sequence receptor complex" EXACT "SRP" EXACT
Secondary IDs

External Crossreferences & Linkouts
	Wikipedia:Signal_recognition_particle