FB2026_02 , released June 18, 2026

CV Term Report

Help Close All Open All

General Information

Term

eukaryotic translation initiation factor 3 complex

ID (Ontology)

GO:0005852 (Gene Ontology)

Definition

A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.[ PubMed:15904532 ]

Also Known As

"eIF-3" ; "eIF3"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_CELLULAR_COMPONENT

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
eukaryotic translation initiation factor 3 complex (all annotations which use CV term, excluding "NOT" statements)
part_of \| eukaryotic translation initiation factor 3 complex

Spanning Tree (Parents/Children)

cellular_component
 |__protein-containing complex______
intracellular anatomical structure  |
 |__cytoplasm_______________________|
cellular anatomical structure       |
 |__cytoplasm_______________________|
                                    eukaryotic translation initiation factor 3 complex  16 rec.
                                     |__eukaryotic translation initiation factor 3 complex, eIF3e 2 rec.
                                     |__eukaryotic translation initiation factor 3 complex, eIF3m 4 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	protein-containing complex
Part of	cytoplasm
Synonyms & Secondary IDs
Synonyms
	"eIF-3" EXACT "eIF3" EXACT
Secondary IDs

External Crossreferences & Linkouts