FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term complement activation ID (Ontology) GO:0006956 (Gene Ontology)
Definition Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.[ ISBN:0781735149 ]
Also Known As "complement cascade" ; "complement response"
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immune system process
 |__immune effector process_____________
 |__activation of immune response_______|
immune response                         |
 |__humoral immune response_____________|
positive regulation of immune response  |
 |__activation of immune response_______|
                                        complement activation
                                         |__activation of membrane attack complex
                                         |   |__regulation of activation of membrane attack complex(+)
                                         |__complement activation, alternative pathway
                                         |   |__regulation of complement activation, alternative pathway(+)
                                         |__complement activation, classical pathway
                                         |   |__regulation of complement activation, classical pathway(+)
                                         |__complement activation, GZMK pathway
                                         |__complement activation, lectin pathway
                                         |   |__regulation of complement activation, lectin pathway(+)
                                         |__regulation of complement activation
                                             |__negative regulation of complement activation(+)
                                             |__positive regulation of complement activation(+)
                                             |__regulation of activation of membrane attack complex(+)
                                             |__regulation of complement activation, alternative pathway(+)
                                             |__regulation of complement activation, classical pathway(+)
                                             |__regulation of complement activation, lectin pathway(+)
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Is a immune effector process
activation of immune response
humoral immune response
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Synonyms
  • "complement activity" RELATED
    "complement cascade" EXACT
    "complement response" EXACT
Secondary IDs
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Reactome:R-HSA-166658 "Complement cascade"