FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term gamma-glutamyl carboxylase activity ID (Ontology) GO:0008488 (Gene Ontology)
Definition Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide.[ PubMed:18374194 ]
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 gamma-glutamyl carboxylase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | gamma-glutamyl carboxylase activity
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  carbon-carbon lyase activity
   |__carboxy-lyase activity
       |__gamma-glutamyl carboxylase activity  1 rec.
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EC:4.1.1.90
Reactome:R-HSA-159752 "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S)"
Reactome:R-HSA-159761 "GGCX gamma-carboxylates F7(21-466) (pro-factor VII)"
Reactome:R-HSA-159795 "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain)"
Reactome:R-HSA-159803 "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX)"
Reactome:R-HSA-159819 "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain)"
Reactome:R-HSA-159826 "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin)"
Reactome:R-HSA-163810 "GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6)"
Reactome:R-HSA-163820 "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z)"
Reactome:R-HSA-6807214 "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin)"
Reactome:R-HSA-9673231 "GGCX does not gamma-carboxylate 3D-F9(29-461) (pro-factor IX)"
RHEA:45140