FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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Term (R,S)-4-hydroxy-2-oxoglutarate aldolase activity ID (Ontology) GO:0008700 (Gene Ontology)
Definition Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. Can act on both the (4R) and the (4S) enantiomers of 4-hydroxy-2-oxoglutarate.[ EC:4 ]
Also Known As "2-keto-4-hydroxyglutarate aldolase activity"
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  carbon-carbon lyase activity
   |__oxo-acid-lyase activity
       |__(R,S)-4-hydroxy-2-oxoglutarate aldolase activity
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Is a oxo-acid-lyase activity
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Synonyms
  • "2-keto-4-hydroxybutyrate aldolase activity" RELATED[ EC:4 ]
    "2-keto-4-hydroxyglutarate aldolase activity" EXACT[ EC:4 ]
    "2-keto-4-hydroxyglutaric aldolase activity" RELATED[ EC:4 ]
    "2-oxo-4-hydroxyglutarate aldolase activity" RELATED[ EC:4 ]
    "2-oxo-4-hydroxyglutaric aldolase activity" RELATED[ EC:4 ]
    "4-hydroxy-2-ketoglutarate aldolase activity" RELATED[ EC:4 ]
    "4-hydroxy-2-ketoglutaric aldolase activity" RELATED[ EC:4 ]
    "4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)" RELATED[ EC:4 ]
    "4-hydroxy-2-oxoglutarate glyoxylate-lyase activity" RELATED[ EC:4 ]
    "DL-4-hydroxy-2-ketoglutarate aldolase activity" RELATED[ EC:4 ]
    "hydroxyketoglutarate aldolase activity" RELATED[ EC:4 ]
    "hydroxyketoglutaric aldolase activity" RELATED[ EC:4 ]
    "KHG-aldolase activity" RELATED[ EC:4 ]
Secondary IDs
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EC:4.1.3.16
MetaCyc:4OH2OXOGLUTARALDOL-RXN
Reactome:R-HSA-6784423 "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate"
RHEA:18169
RHEA:30687