FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term type I site-specific deoxyribonuclease activity ID (Ontology) GO:0009035 (Gene Ontology)
Definition Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions, driven by ATP hydrolysis. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA.[ PubMed:15300241 PubMed:15788748 ]
Also Known As "type I restriction enzyme activity"
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DNA endonuclease activity
 |__restriction endodeoxyribonuclease activity_________________
 |__DNA endonuclease activity, producing 5'-phosphomonoesters__|
ATP-dependent activity, acting on DNA                          |
 |__DNA translocase activity___________________________________|
hydrolase activity, acting on ester bonds                      |
 |__restriction endodeoxyribonuclease activity_________________|
 |__DNA endonuclease activity, producing 5'-phosphomonoesters__|
                                                               type I site-specific deoxyribonuclease activity
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Is a DNA translocase activity
restriction endodeoxyribonuclease activity
DNA endonuclease activity, producing 5'-phosphomonoesters
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Synonyms
  • "adenosine triphosphate-dependent deoxyribonuclease activity" RELATED[ EC:3 ]
    "ATP-dependent DNase activity" RELATED[ EC:3 ]
    "deoxyribonuclease (adenosine triphosphate-hydrolyzing)" RELATED[ EC:3 ]
    "deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)" RELATED[ EC:3 ]
    "type I restriction enzyme activity" EXACT
Secondary IDs
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EC:3.1.21.3
MetaCyc:3.1.21.3-RXN