FB2026_03 , released September 17, 2026

CV Term Report

Help Close All Open All

General Information

Term

regulatory ncRNA-mediated gene silencing

ID (Ontology)

GO:0031047 (Gene Ontology)

Definition

A process in which an regulatory non-coding RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation.[ PubMed:15020054 ]

Also Known As

"RNA-dependent gene silencing"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
regulatory ncRNA-mediated gene silencing (all annotations which use CV term, excluding "NOT" statements)
involved_in \| regulatory ncRNA-mediated gene silencing

Spanning Tree (Parents/Children)

regulation of gene expression______________________________
negative regulation of macromolecule biosynthetic process__|
                                                           negative regulation of gene expression
                                                            |__regulatory ncRNA-mediated gene silencing  260 rec.
                                                                |__co-transcriptional gene silencing by RNA interference machinery
                                                                |__regulatory ncRNA-mediated heterochromatin formation 35 rec.
                                                                |   |__piRNA-mediated heterochromatin formation(+) 24 rec.
                                                                |   |__siRNA-mediated heterochromatin formation(+) 6 rec.
                                                                |__regulatory ncRNA-mediated post-transcriptional gene silencing 199 rec.
                                                                    |__lncRNA-mediated post-transcriptional gene silencing 1 rec.
                                                                    |__miRNA-mediated post-transcriptional gene silencing(+) 162 rec.
                                                                    |__piRNA-mediated gene silencing by mRNA destabilization(+) 12 rec.
                                                                    |__RNAi-mediated antiviral immune response(+) 5 rec.
                                                                    |__siRNA-mediated post-transcriptional gene silencing(+) 1 rec.
                                                                    |__sRNA-mediated post-transcriptional gene silencing
                                                                    |__transitive RNA interference(+)

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	negative regulation of gene expression
Part of
Synonyms & Secondary IDs
Synonyms
	"gene silencing by RNA" RELATED "RNA-dependent gene silencing" EXACT "RNA-mediated gene silencing" RELATED
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-211000 "Gene Silencing by RNA"