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General Information
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| Term |
ubiquitin-dependent protein catabolic process via the C-end degron rule pathway |
ID (Ontology) |
GO:0140627 (Gene Ontology) |
| Definition |
The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the DesCEND (destruction via C-end degron) pathway. In the DesCEND pathway, C-terminal residues (C-end degrons) in substrates are recognized by Cul2-RING and Cul4-RING E3 ligases, whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. C-end degrons can be present in full-length proteins, truncated proteins or proteolytically cleaved forms.[ PubMed:29775578 PubMed:29779948 ] |
| Also Known As |
"DesCEND" |
| Comment |
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Links to External Ontologies
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QuickGO data AmiGO data
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Annotations
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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| Data Class | Field | Records |
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| Genes (FBgn) | GO_BIOLOGICAL_PROCESS | 1 |
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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| Full annotation statements | Relevant FlyBase reports |
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| Genes |
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ubiquitin-dependent protein catabolic process via the C-end degron rule pathway (all annotations which use CV term, excluding "NOT" statements) | 1 | involved_in | ubiquitin-dependent protein catabolic process via the C-end degron rule pathway | 1 |
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Relationships
