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| Term | iNOS-S100A8/A9 complex | ID (Ontology) | GO:1990657 (Gene Ontology) |
| Definition | A protein complex capable of stimulus-inducible nitric-oxide synthase activity. S-nitrosylates cysteine residues in target proteins, a principal mechanism of nitric oxide (NO)-mediated signal transduction. In mammals consists of NOS2, S100A8 and S100A9. S100A9 acts both as an adaptor linking NOS2 to its target and as a transnitrosylase that transfers the nitric oxide moiety from NOS2 to its target, via its own S-nitrosylated cysteine.[ PubMed:25417112 ] | ||
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cytoplasm |__transnitrosylase complex_______ oxidoreductase complex | |__nitric-oxide synthase complex__| transferase complex | |__transnitrosylase complex_______| iNOS-S100A8/A9 complex |
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nitric-oxide synthase complex transnitrosylase complex |
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