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| Term | domain profile pairs | ID (Ontology) | MI:0037 (Molecular Interactions) |
| Definition | This approach uses a protein interaction network of a given organism to infer interaction in another organism using information about the interacting region. The regions or domains involved in interactions are clustered if they share sequence similarity and have common interacting partners. The resulting domain profiles are then used to screen the proteome of another organism and domain-domain interactions are inferred. Ultimately, an inferred protein interaction map is built in this second organism.[ PubMed:11473021 ] | ||
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feature detection method |__feature prediction____________ interaction prediction | |__experimental knowledge based__| |__sequence based prediction_____| domain profile pairs |
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experimental knowledge based sequence based prediction feature prediction |
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