FB2026_03 , released September 17, 2026
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Term neurodegenerative disease ID (Ontology) DOID:1289 (Human Disease)
Definition A central nervous system disease that results in the progressive deterioration of function or structure of neurons.
Also Known As"degenerative disease"
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Data ClassFieldDirect annotations
Alleles (FBal)HUMAN_DISEASE_INTERACTIONS
Human Disease Models (FBhh)DOID32 (maintenance)
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 Alleles Genes Human Disease Models
 neurodegenerative disease
 ameliorates | neurodegenerative disease
      --       --
 exacerbates | neurodegenerative disease
      --       --
 model of | neurodegenerative disease
      --       --
 DOES NOT ameliorate | neurodegenerative disease
      --       --
 DOES NOT exacerbate | neurodegenerative disease
      --       --
 DOES NOT model | neurodegenerative disease
      --       --
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  nervous system disease
   |__central nervous system disease
       |__neurodegenerative disease  7187 rec.
           |__agenesis of the corpus callosum with peripheral neuropathy 1 rec.
           |__amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 1 rec.
           |__childhood-onset neurodegeneration with brain atrophy 4 rec.
           |__familial encephalopathy with neuroserpin inclusion bodies 19 rec.
           |__hereditary ataxia 1256 rec.
           |   |__autosomal dominant sensory ataxia 1
           |   |__cerebellar ataxia(+) 1094 rec.
           |   |__episodic ataxia(+) 28 rec.
           |   |__spastic ataxia(+) 10 rec.
           |   |__X-linked hereditary ataxia(+) 130 rec.
           |__Huntington's disease 1037 rec.
           |__Huntington's disease-like 2 5 rec.
           |__infantile cerebellar-retinal degeneration 4 rec.
           |__motor neuron disease 2123 rec.
           |   |__amyotrophic lateral sclerosis(+) 1903 rec.
           |   |__anterior horn cell disease
           |   |__lateral sclerosis
           |   |__motor neuritis(+)
           |   |__multisystem proteinopathy
           |   |__nonparalytic poliomyelitis
           |   |__progressive bulbar palsy(+) 1 rec.
           |   |__progressive muscular atrophy
           |   |__scapuloperoneal spinal muscular atrophy 3 rec.
           |   |__spinal muscular atrophy(+) 236 rec.
           |__myoclonic cerebellar dyssynergia
           |__neuroacanthocytosis 5 rec.
           |   |__choreaacanthocytosis 5 rec.
           |   |__McLeod syndrome
           |__neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset 4 rec.
           |__neurodegeneration with brain iron accumulation 49 rec.
           |   |__neurodegeneration with brain iron accumulation 2a 8 rec.
           |   |__neurodegeneration with brain iron accumulation 2b 3 rec.
           |   |__neurodegeneration with brain iron accumulation 3 3 rec.
           |   |__neurodegeneration with brain iron accumulation 4 10 rec.
           |   |__neurodegeneration with brain iron accumulation 5 2 rec.
           |   |__neurodegeneration with brain iron accumulation 6 3 rec.
           |   |__pantothenate kinase-associated neurodegeneration 14 rec.
           |__neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures 22 rec.
           |__neuronal intranuclear inclusion disease 7 rec.
           |__olivopontocerebellar atrophy 66 rec.
           |__plexopathy
           |__pontocerebellar hypoplasia 42 rec.
           |   |__pontocerebellar hypoplasia type 1(+) 14 rec.
           |   |__pontocerebellar hypoplasia type 2(+) 5 rec.
           |   |__pontocerebellar hypoplasia type 3
           |   |__pontocerebellar hypoplasia type 4 7 rec.
           |   |__pontocerebellar hypoplasia type 5 1 rec.
           |   |__pontocerebellar hypoplasia type 6 1 rec.
           |   |__pontocerebellar hypoplasia type 7
           |   |__pontocerebellar hypoplasia type 8 1 rec.
           |   |__pontocerebellar hypoplasia type 9 1 rec.
           |   |__pontocerebellar hypoplasia type 10 6 rec.
           |   |__pontocerebellar hypoplasia type 11 1 rec.
           |   |__pontocerebellar hypoplasia type 12 1 rec.
           |   |__pontocerebellar hypoplasia type 13 1 rec.
           |   |__pontocerebellar hypoplasia type 14 1 rec.
           |   |__pontocerebellar hypoplasia type 15 1 rec.
           |   |__pontocerebellar hypoplasia type 16 2 rec.
           |__primary cerebellar degeneration
           |__secondary Parkinson disease
           |   |__postencephalitic Parkinson disease
           |__SPOAN syndrome 1 rec.
           |__stress-induced childhood-onset neurodegeneration with variable ataxia and seizures 3 rec.
           |__synucleinopathy 1223 rec.
           |   |__multiple system atrophy(+) 4 rec.
           |   |__Parkinson's disease(+) 1205 rec.
           |__tauopathy 2016 rec.
               |__Alzheimer's disease(+) 957 rec.
               |__chronic traumatic encephalopathy
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  • "degenerative disease" EXACT
Secondary IDs
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ICD10CM:G31.9
MESH:D019636
NCI:C195952
NCI:C27090
SNOMEDCT_US_2025_09_01:362975008
UMLS_CUI:C0524851
UMLS_CUI:C1285162