FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

enhancer trap

ID (Ontology)

FBcv:0005069 (FlyBase CV)

Definition

An enhancer trap cassette is designed to report or utilize the expression of endogenous enhancer elements upon integration of the cassette into the genome. The basic components of an enhancer trap cassette are a minimal promoter element fused upstream of a gene. Upon integration into the genome, a neighboring genomic enhancer may activate expression of the gene encoded by the enhancer trap cassette. Depending on the nature of this gene, the insertion may directly report the expression pattern of the 'trapped' enhancer (e.g. if the gene encodes a reporter enzyme or fluorescent protein), or it may be used to drive expression of any gene of interest (e.g. if the gene encodes a driver that forms part of a binary expression system). An enhancer trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR. An enhancer trap insertion can be mutagenic, disrupting the function of an endogenous locus, depending on the particular insertion site.[ FlyBase:FBrf0128252 FlyBase:FBrf0216478 PubMed:10899970 ]

Comment

Links to External Ontologies

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Constructs (FBtp)	USES	4 (no records in this data class)

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Alleles	Constructs
enhancer trap (all annotations which use CV term, excluding "NOT" statements)

Spanning Tree (Parents/Children)

  experimental tool descriptor
   |__insertional mutagenesis tool
       |__enhancer trap  123 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	insertional mutagenesis tool
Part of
Synonyms & Secondary IDs
Synonyms
	"enhancer detection tool" RELATED
Secondary IDs

External Crossreferences & Linkouts
	SO:0001479