FB2026_03 , released September 17, 2026
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Term integrase target site ID (Ontology) FBcv:0005079 (FlyBase CV)
Definition A recognition site for an integrase, an enzyme that mediates an exchange reaction between two DNA templates, resulting in integration of DNA from one of the templates into the other. An integrase binds a pair of compatible recognition sites (typically called attP and attB) which each contain a short integration core flanked by imperfect inverted repeats that are not identical. Exchange between the attP/attB pair results in the formation of hybrid sites (typically called attL and attR) that are no longer a substrate of the integrase. Thus the exchange reaction driven by an integrase is unidirectional. Mutually exclusive pairs of recognition site have been engineered for some integrases. Integrases can be used to generate many different types of genetic modification, with the outcome being influenced by the relative orientation (direct or inverted), relative location and composition of the two recognition sites. The types of possible modification include deletion of DNA, generation of chromosomal rearrangements, integration of DNA into the genome, and replacement of genetic material with that from a donor plasmid using recombination-mediated cassette exchange (RMCE).[ FlyBase:FBrf0231034 ]
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 integrase target site (all annotations which use CV term, excluding "NOT" statements)
     carries tool | integrase target site
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       |__integrase target site  10 rec.
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