FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term protein kinase activity ID (Ontology) GO:0004672 (Gene Ontology)
Definition Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.[ PubMed:25399640 ]
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION     210
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 Full annotation statements 
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 Gene Groups Genes
 protein kinase activity (all annotations which use CV term, excluding "NOT" statements)       3    210
     enables | protein kinase activity       --     210
 NOT | enables | protein kinase activity       --      22
Spanning Tree (Parents/Children)
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catalytic activity
 |__catalytic activity, acting on a protein______________________
transferase activity, transferring phosphorus-containing groups  |
 |__kinase activity______________________________________________|
 |__phosphotransferase activity, alcohol group as acceptor_______|
                                                                 protein kinase activity  266 rec.
                                                                  |__beta-adrenergic receptor kinase activity
                                                                  |__cyclin-dependent protein kinase activity 19 rec.
                                                                  |   |__cyclin-dependent protein serine/threonine kinase activity 19 rec.
                                                                  |__histidine phosphotransfer kinase activity
                                                                  |__histone kinase activity 6 rec.
                                                                  |   |__histone H1 kinase activity(+)
                                                                  |   |__histone H2A kinase activity(+) 1 rec.
                                                                  |   |__histone H2AX kinase activity(+)
                                                                  |   |__histone H2B kinase activity(+)
                                                                  |   |__histone H3 kinase activity(+) 3 rec.
                                                                  |   |__histone H4 kinase activity(+)
                                                                  |__protein arginine kinase activity
                                                                  |__protein histidine kinase activity
                                                                  |   |__phosphorelay sensor kinase activity
                                                                  |   |__protein histidine pros-kinase activity
                                                                  |   |__protein histidine tele-kinase activity
                                                                  |   |__transmembrane receptor histidine kinase activity(+)
                                                                  |__protein serine kinase activity 1 rec.
                                                                  |   |__[isocitrate dehydrogenase (NADP+)] kinase activity
                                                                  |__protein serine kinase activity (using GTP as donor)
                                                                  |__protein serine/threonine kinase activity 218 rec.
                                                                  |   |__3-phosphoinositide-dependent protein kinase activity 1 rec.
                                                                  |   |__[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
                                                                  |   |__[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
                                                                  |   |__[tyrosine 3-monooxygenase] kinase activity
                                                                  |   |__AMP-activated protein kinase activity 2 rec.
                                                                  |   |__calcium-dependent protein serine/threonine kinase activity(+) 6 rec.
                                                                  |   |__calcium/calmodulin-dependent protein kinase activity(+) 8 rec.
                                                                  |   |__cyclic nucleotide-dependent protein kinase activity(+) 9 rec.
                                                                  |   |__cyclin-dependent protein serine/threonine kinase activity 19 rec.
                                                                  |   |__diacylglycerol-dependent serine/threonine kinase activity(+) 6 rec.
                                                                  |   |__DNA-dependent protein kinase activity
                                                                  |   |__eukaryotic translation initiation factor 2alpha kinase activity 2 rec.
                                                                  |   |__Fas-activated serine/threonine kinase activity
                                                                  |   |__G protein-coupled receptor kinase activity(+) 2 rec.
                                                                  |   |__GTP-dependent protein kinase activity
                                                                  |   |__histone H1-4S27 kinase activity
                                                                  |   |__histone H1-4S35 kinase activity
                                                                  |   |__histone H1-4S187 kinase activity
                                                                  |   |__histone H2AS1 kinase activity
                                                                  |   |__histone H2AT120 kinase activity 1 rec.
                                                                  |   |__histone H2AXS139 kinase activity
                                                                  |   |__histone H2BS14 kinase activity
                                                                  |   |__histone H2BS36 kinase activity
                                                                  |   |__histone H3S10 kinase activity 1 rec.
                                                                  |   |__histone H3S28 kinase activity
                                                                  |   |__histone H3S57 kinase activity
                                                                  |   |__histone H3T3 kinase activity 1 rec.
                                                                  |   |__histone H3T6 kinase activity
                                                                  |   |__histone H3T11 kinase activity 1 rec.
                                                                  |   |__histone H3T45 kinase activity
                                                                  |   |__histone H4S1 kinase activity
                                                                  |   |__IkappaB kinase activity 1 rec.
                                                                  |   |__MAP kinase activity(+) 8 rec.
                                                                  |   |__MAP kinase kinase kinase activity(+) 8 rec.
                                                                  |   |__MAP kinase kinase kinase kinase activity(+) 2 rec.
                                                                  |   |__myosin light chain kinase activity 3 rec.
                                                                  |   |__pyruvate dehydrogenase (acetyl-transferring) kinase activity 1 rec.
                                                                  |   |__Rho-dependent protein serine/threonine kinase activity 1 rec.
                                                                  |   |__ribosomal protein S6 kinase activity 2 rec.
                                                                  |   |__RNA polymerase II CTD heptapeptide repeat kinase activity(+) 5 rec.
                                                                  |   |__tau-protein kinase activity 5 rec.
                                                                  |   |__transmembrane receptor protein serine/threonine kinase activity(+) 8 rec.
                                                                  |__protein serine/threonine/tyrosine kinase activity 11 rec.
                                                                  |   |__MAP kinase kinase activity(+) 5 rec.
                                                                  |__protein tyrosine kinase activity 33 rec.
                                                                  |   |__histone H2AXY142 kinase activity
                                                                  |   |__histone H3Y41 kinase activity
                                                                  |   |__non-membrane spanning protein tyrosine kinase activity 13 rec.
                                                                  |   |__transmembrane receptor protein tyrosine kinase activity(+) 18 rec.
                                                                  |__transmembrane receptor protein kinase activity 26 rec.
                                                                      |__transmembrane receptor histidine kinase activity(+)
                                                                      |__transmembrane receptor protein serine/threonine kinase activity(+) 8 rec.
                                                                      |__transmembrane receptor protein tyrosine kinase activity(+) 18 rec.
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Is a kinase activity
phosphotransferase activity, alcohol group as acceptor
catalytic activity, acting on a protein
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Synonyms
  • "protamine kinase activity" NARROW
Secondary IDs
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Reactome:R-HSA-156832 "INF-gamma induced phosphorylation of L13a"
Reactome:R-HSA-5693148 "BCKDK phosphorylates BCKDH"
Reactome:R-HSA-937034 "IRAK1 phosphorylates Pellino"
Reactome:R-HSA-9604606 "Unknown kinase phosphorylates NICD4"
Reactome:R-HSA-9673284 "GTP-bound RAC1 contributes to MAPK8 activation"
Reactome:R-HSA-9732753 "JAK1-activated RAF1 phosphorylates MAPKs"
Reactome:R-HSA-975139 "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation"
Reactome:R-HSA-9833820 "PKR dimer autophosphorylates"
Reactome:R-HSA-9835885 "p-PKR dimer phosphorylates eIF2-alpha"
Reactome:R-HSA-9836159 "p-PKR dimer phosphorylates DHX9"
Reactome:R-HSA-9836184 "p-PKR dimer phosphorylates CDK1"
Reactome:R-HSA-9836322 "p-PKR dimer phosphorylates MKK6"
Reactome:R-HSA-9836362 "p-PKR dimer phosphorylates TP53 tetramer"
Reactome:R-HSA-9836383 "p-PKR dimer phosphorylates ILF3:ILF2"
Reactome:R-HSA-9836404 "p-PKR dimer phosphorylates MAPT"
Reactome:R-HSA-9836435 "p-PKR dimer phosphorylates SNCA"
Reactome:R-HSA-9836449 "p-PKR dimer phosphorylates HIV tat"
Reactome:R-HSA-9836515 "p-PKR dimer phosphorylates PTPN2"
Reactome:R-HSA-9836617 "p-PKR dimer phosphorylates SPHK1"
Reactome:R-HSA-9836664 "p-PKR dimer phosphorylates PPP2R5A"