FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term transmembrane receptor protein tyrosine kinase activity ID (Ontology) GO:0004714 (Gene Ontology)
Definition Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.[ EC:2 ]
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      16
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 transmembrane receptor protein tyrosine kinase activity (all annotations which use CV term, excluding "NOT" statements)       1     16
     enables | transmembrane receptor protein tyrosine kinase activity       --      16
 NOT | enables | transmembrane receptor protein tyrosine kinase activity       --       1
Spanning Tree (Parents/Children)
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protein kinase activity
 |__protein tyrosine kinase activity________________
 |__transmembrane receptor protein kinase activity__|
transmembrane signaling receptor activity           |
 |__transmembrane receptor protein kinase activity__|
                                                    transmembrane receptor protein tyrosine kinase activity  18 rec.
                                                     |__boss receptor activity 1 rec.
                                                     |__brain-derived neurotrophic factor receptor activity
                                                     |__ephrin receptor activity 1 rec.
                                                     |   |__GPI-linked ephrin receptor activity
                                                     |   |__transmembrane-ephrin receptor activity 1 rec.
                                                     |__epidermal growth factor receptor activity 1 rec.
                                                     |__fibroblast growth factor receptor activity 2 rec.
                                                     |__hepatocyte growth factor receptor activity
                                                     |__insulin receptor activity 1 rec.
                                                     |__insulin-like growth factor receptor activity
                                                     |__macrophage colony-stimulating factor receptor activity
                                                     |__placental growth factor receptor activity
                                                     |__platelet-derived growth factor receptor activity
                                                     |   |__platelet-derived growth factor alpha-receptor activity
                                                     |   |__platelet-derived growth factor beta-receptor activity
                                                     |__protein tyrosine kinase collagen receptor activity 1 rec.
                                                     |__stem cell factor receptor activity
                                                     |__vascular endothelial growth factor receptor activity
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Is a protein tyrosine kinase activity
transmembrane receptor protein kinase activity
Part of
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Synonyms
  • "receptor protein tyrosine kinase activity" RELATED[ EC:2 ]
    "receptor protein-tyrosine kinase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.7.10.1
Reactome:R-HSA-166544 "TrkA receptor autophosphorylates"
Reactome:R-HSA-167019 "SHC, complexed with TrkA, is tyrosine-phosphorylated"
Reactome:R-HSA-167683 "TrkA phosphorylates PLCG1"
Reactome:R-HSA-169905 "ARMS is phosphorylated by active TrkA receptor"
Reactome:R-HSA-177930 "GAB1 phosphorylation by EGFR kinase"
Reactome:R-HSA-177933 "SHC1 phosphorylation by phosphorylated EGFR"
Reactome:R-HSA-198295 "TRKA phosphorylates IRS"
Reactome:R-HSA-6784324 "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA"
Reactome:R-HSA-74711 "Phosphorylation of IRS"
Reactome:R-HSA-74742 "Phosphorylation of SHC1"
Reactome:R-HSA-8852552 "MST1R autophosphorylates"
Reactome:R-HSA-8853792 "RET tyrosine phosphorylation"
Reactome:R-HSA-8950269 "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor"
Reactome:R-HSA-8950340 "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation"
Reactome:R-HSA-8950354 "STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction"
Reactome:R-HSA-8950364 "IL23R in IL23:IL23 receptor complex is phosphorylated"
Reactome:R-HSA-8950405 "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated"
Reactome:R-HSA-8950423 "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated"
Reactome:R-HSA-8950453 "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4"
Reactome:R-HSA-8950485 "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction"
Reactome:R-HSA-8950537 "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated"
Reactome:R-HSA-8950591 "JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated"
Reactome:R-HSA-8950757 "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated"
Reactome:R-HSA-8982163 "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3"
Reactome:R-HSA-8983300 "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1"
Reactome:R-HSA-8983309 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1"
Reactome:R-HSA-8983371 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5"
Reactome:R-HSA-8983424 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2"
Reactome:R-HSA-8986985 "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5"
Reactome:R-HSA-8986994 "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2"
Reactome:R-HSA-8986995 "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA"
Reactome:R-HSA-8987012 "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1"
Reactome:R-HSA-8987040 "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1"
Reactome:R-HSA-8987042 "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2"
Reactome:R-HSA-8987070 "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3"
Reactome:R-HSA-8987084 "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1"
Reactome:R-HSA-8987096 "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3"
Reactome:R-HSA-8987129 "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated"
Reactome:R-HSA-8987141 "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3"
Reactome:R-HSA-8987150 "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3"
Reactome:R-HSA-8987179 "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3"
Reactome:R-HSA-8987202 "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2"
Reactome:R-HSA-8987255 "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3"