FB2026_02 , released June 18, 2026

CV Term Report

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General Information

Term

nuclear receptor activity

ID (Ontology)

GO:0004879 (Gene Ontology)

Definition

A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus.[ PubMed:23457262 ]

Also Known As

"ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity" ; "RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
nuclear receptor activity (all annotations which use CV term, excluding "NOT" statements)
contributes_to \| nuclear receptor activity
enables \| nuclear receptor activity

Spanning Tree (Parents/Children)

DNA-binding transcription factor activity
 |__DNA-binding transcription factor activity, RNA polymerase II-specific__
 |__ligand-modulated transcription factor activity_________________________|
molecular transducer activity                                              |
 |__signaling receptor activity____________________________________________|
                                                                           nuclear receptor activity  23 rec.
                                                                            |__bile acid nuclear receptor activity
                                                                            |__nuclear steroid receptor activity 4 rec.
                                                                                |__nuclear estrogen receptor activity
                                                                                |__nuclear glucocorticoid receptor activity(+)

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	DNA-binding transcription factor activity, RNA polymerase II-specific signaling receptor activity ligand-modulated transcription factor activity
Part of
Synonyms & Secondary IDs
Synonyms
	"1,25-(OH)2D3 receptor activity" NARROW "9-cis retinoic acid receptor activity" NARROW "androgen receptor activity" NARROW "calcitriol receptor activity" NARROW "ecdysteroid hormone receptor activity" NARROW "estrogen nuclear receptor activity" NARROW "glucocorticoid receptor activity" NARROW "juvenile hormone receptor activity" NARROW "ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity" EXACT "ligand-dependent nuclear receptor activity" RELATED "ligand-dependent transcription factor activity" RELATED "nuclear hormone receptor" NARROW "retinoic acid receptor activity" NARROW "retinoid-X receptor activity" NARROW "RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding" NARROW "RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding" NARROW "RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding" EXACT "RXR" NARROW "thyroid hormone receptor activity" NARROW "vitamin A receptor activity" NARROW "vitamin D receptor activity" NARROW "vitamin D3 receptor activity" NARROW
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-400143 "Fatty acid ligands activate PPARA" Reactome:R-HSA-8936849 "AHR:2xHSP90:AIP:PTGES3 binds TCDD" Reactome:R-HSA-8937169 "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm" Reactome:R-HSA-8937191 "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates"