FB2026_02 , released June 18, 2026

CV Term Report

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General Information

Term

RNA polymerase II cis-regulatory region sequence-specific DNA binding

ID (Ontology)

GO:0000978 (Gene Ontology)

Definition

Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Vocabulary search and annotation result lists are temporarily unavailable. Term reports and hierarchy navigation remain available.

Genes: 386

Results list data from multiple species. Annotation result lists are temporarily unavailable.

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports (result lists: maintenance)
Full annotation statements	Genes
RNA polymerase II cis-regulatory region sequence-specific DNA binding (all annotations which use CV term, excluding "NOT" statements)	368
contributes_to \| RNA polymerase II cis-regulatory region sequence-specific DNA binding	5
enables \| RNA polymerase II cis-regulatory region sequence-specific DNA binding	365

Spanning Tree (Parents/Children)

transcription cis-regulatory region binding
 |__RNA polymerase II transcription regulatory region sequence-specific DNA binding__
 |__cis-regulatory region sequence-specific DNA binding______________________________|
                                                                                     RNA polymerase II cis-regulatory region sequence-specific DNA binding  386 rec.
                                                                                      |__cAMP response element binding 2 rec.
                                                                                      |__carbohydrate response element binding
                                                                                      |__E-box binding 11 rec.
                                                                                      |__estrogen response element binding 5 rec.
                                                                                      |__GC-box binding
                                                                                      |__juvenile hormone response element binding 2 rec.
                                                                                      |__N-box binding
                                                                                      |__retinoic acid-responsive element binding
                                                                                      |__RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending
                                                                                      |__serum response element binding
                                                                                      |__sterol response element binding
                                                                                      |__vitamin D response element binding

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding
Part of
Synonyms & Secondary IDs
Synonyms
	"RNA polymerase II core promoter proximal region sequence-specific DNA binding" RELATED "RNA polymerase II distal enhancer sequence-specific DNA binding" RELATED "RNA polymerase II promoter proximal region sequence-specific DNA binding" RELATED "RNA polymerase II proximal promoter sequence-specific DNA binding" RELATED "RNA polymerase II upstream activating sequence (UAS) sequence-specific DNA binding" RELATED
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-400204 "PPARA binds RXRA"