FlyBase error report for CG1004 on Tue Oct 16 22:17:41 2001. - Urban, S. (2001)
Gene or accession: CG1004 Release: 2 Missed gene Comments: Although the precise role of Rhomboid in triggering EGF receptor signalling has remained elusive, we have now determined its mechanism. Rhomboid-1 is an intramembrane serine protease that cleaves the three TGFa-like EGF ligands in Drosophila, thus activating them as signals. The cleavage occurs within their transmembrane domains. Rhomboid-1 is localized in the Golgi apparatus, and this is the compartment where cleavage of the ligand occurs (not at the plasma membrane). The other fly Rhomboids (2,3, and 4) are also intramembrane serine proteases that catalyze the proteolytic release of these ligands. This work is published in the following articles: Urban, S, Lee J. R., and M. Freeman. Drosophila Rhomboid-1 defines a family of putative intramembrane serine proteases. (2001). Cell 107: in press [Oct 19th issue]. Lee J. R., Urban, S, Garvey C. F., and M. Freeman. Regulated intracellular transport and proteolysis control EGF ligand activation in Drosophila. (2001). Cell 107: in press [Oct 19th issue].