FlyBase Aberration Report: Dmel\Df(1)N-8

General Information

Symbol

Df(1)N-8

Species

D. melanogaster

Name

Deficiency (1) Notch

FlyBase ID

FBab0000579

Feature type

chromosomal_deletion

Also Known As

Df(1)N⁸, Df(1)N8, N⁸, N8

Computed Breakpoints include

3C1;3D6

Features within 3C1--3D6

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

spontaneous

(Eeken and Sobels, 1990, Slizynska, 1938)

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Vervoort et al., 1997, Duffy et al., 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Eeken and Sobels, 1990, Wieschaus et al., 1984, Slizynska, 1938)

Breakpoints

3C1-3C2;3D5-3D6

(Slizynska, 1938)

3B4-3C1;3D6-3E1

(Wieschaus et al., 1984)

3C1-3C2;3E2-3E3

(Eeken and Sobels, 1990)

3C2-3C3;3E3-3E4

(Vervoort et al., 1997, Duffy et al., 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

l(1)3Bf << bk1 << crm << l(1)EA65 << bk2 << l(1)3Eb

Genetic mapping information

Comments

Comments on Cytology

Deletion of 17/19 bands.

(Eeken and Sobels, 1990)

Ref: FBrf0034104

(Wieschaus et al., 1984)

Left limit of break 1 from polytene analysis (FBrf0004288) Right limit of break 1 from inclusion of crm (FBrf0038033) Left limit of break 2 from polytene analysis (FBrf0040178) Right limit of break 2 from polytene analysis (FBrf0004288)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

crm

(Lin and Wolfner, 1989, Thierry-Mieg, 1982)

kirre

(Ruiz-Gomez et al., 2000)

l(1)3Da

(Kramers et al., 1991, Kramers et al., 1983)

l(1)3Db

(Vervoort et al., 1997)

l(1)EA65

(Kramers et al., 1991, Kramers et al., 1983)

l(1)ESHS18

(Eeken et al., 1985)

l(1)ESHS19

(Eeken et al., 1985)

Myc

(Johnston et al., 1999, Kramers et al., 1991, Eeken et al., 1985, Kramers et al., 1983)

(Dietrich et al., 2005, Ruiz-Gomez et al., 2000, Rottgen et al., 1998, Cohen et al., 1997, Harbecke and Lengyel, 1995, Kramers et al., 1991, Lin and Wolfner, 1989, Eeken et al., 1985, Kramers et al., 1983, Thierry-Mieg, 1982, Slizynska, 1938, Mackensen, 1935, Glass, 1933)

rst

(Ruiz-Gomez et al., 2000, Kramers et al., 1991, Lin and Wolfner, 1989, Kramers et al., 1983, Thierry-Mieg, 1982, Slizynska, 1938)

(Ruiz-Gomez et al., 2000, Lin and Wolfner, 1989, Thierry-Mieg, 1982)

(Lloyd et al., 2002, Gailey et al., 1991, Kramers et al., 1991, Lin and Wolfner, 1989, Eeken et al., 1985, Kramers et al., 1983, Thierry-Mieg, 1982, Slizynska, 1938, Mackensen, 1935)

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Actn

(Kramers et al., 1991)

crm

(Kramers et al., 1983)

crn

(Kramers et al., 1991)

dwg

(Kramers et al., 1991, Lin and Wolfner, 1989, Kramers et al., 1983)

(Mackensen, 1935)

egh

(Kramers et al., 1991, Lin and Wolfner, 1989)

fs(1)Ya

(Lin and Wolfner, 1989)

fs(1)Yb

(Lin and Wolfner, 1989)

(Kramers et al., 1991, Lin and Wolfner, 1989)

Klp3A

(Page and Hawley, 2005)

(Kramers et al., 1991)

l(1)2Dj

(Kramers et al., 1991)

l(1)2Dk

(Kramers et al., 1991)

l(1)2Dl

(Kramers et al., 1991)

l(1)2Dm

(Kramers et al., 1991)

l(1)2Ea

(Kramers et al., 1991)

l(1)2Ec

(Kramers et al., 1991)

l(1)2Ed

(Kramers et al., 1991)

l(1)2Fb

(Kramers et al., 1991)

l(1)2Fc

(Kramers et al., 1991)

l(1)2Fd

(Kramers et al., 1991, Eeken et al., 1985)

l(1)2Ff

(Kramers et al., 1991)

l(1)2Fg

(Kramers et al., 1991)

l(1)3-64

(Kramers et al., 1991, Kramers et al., 1983)

l(1)3ABa

(Kramers et al., 1991)

l(1)3ABb

(Kramers et al., 1991)

l(1)3Ag

(Lin and Wolfner, 1989)

l(1)3Aj

(Kramers et al., 1991)

l(1)3Ak

(Kramers et al., 1991)

l(1)3Al

(Kramers et al., 1991)

l(1)3Am

(Kramers et al., 1991)

l(1)3An

(Kramers et al., 1991)

l(1)3Ao

(Kramers et al., 1991)

l(1)3Ap

(Kramers et al., 1991)

l(1)3Aq

(Kramers et al., 1991)

l(1)3Bb

(Kramers et al., 1991, Lin and Wolfner, 1989, Kramers et al., 1983)

l(1)3Bc

(Kramers et al., 1991, Lin and Wolfner, 1989, Kramers et al., 1983)

l(1)3Bd

(Kramers et al., 1991, Lin and Wolfner, 1989, Kramers et al., 1983)

l(1)3Bf

(Kramers et al., 1991, Kramers et al., 1983)

l(1)3Bg

(Kramers et al., 1991)

l(1)3Eb

(Kramers et al., 1991, Kramers et al., 1983)

l(1)3Ed

(Kramers et al., 1991, Kramers et al., 1983)

l(1)7-103

(Kramers et al., 1991, Kramers et al., 1983)

l(1)ESHS6

(Eeken et al., 1985)

l(1)ESHS7

(Eeken et al., 1985)

l(1)ESHS8

(Eeken et al., 1985)

l(1)ESHS9

(Eeken et al., 1985)

l(1)ESHS10

(Eeken et al., 1985)

l(1)ESHS11

(Eeken et al., 1985)

l(1)ESHS12

(Eeken et al., 1985)

l(1)ESHS13

(Eeken et al., 1985)

l(1)ESHS14

(Kramers et al., 1991, Eeken et al., 1985)

l(1)ESHS15

(Eeken et al., 1985)

l(1)ESHS16

(Eeken et al., 1985)

l(1)ESHS17

(Eeken et al., 1985)

l(1)ESHS20

(Eeken et al., 1985)

l(1)ESHS21

(Eeken et al., 1985)

l(1)ESHS22

(Eeken et al., 1985)

l(1)ESHS23

(Eeken et al., 1985)

par

(Thierry-Mieg, 1982)

per

(Gailey et al., 1991, Dushay et al., 1990, Lin and Wolfner, 1989)

Pgd

(Kramers et al., 1991)

Pi4KIIIα

(Kramers et al., 1991, Lin and Wolfner, 1989, Eeken et al., 1985)

(Kramers et al., 1991, Mackensen, 1935)

Raf

(Kramers et al., 1991)

rey

(Sturtevant, 1948)

sgg

(Kramers et al., 1991, Lin and Wolfner, 1989)

tko

(Kramers et al., 1991, Lin and Wolfner, 1989)

trol

(Kramers et al., 1991, Lin and Wolfner, 1989, Eeken et al., 1985)

VhaAC39-1

(Sturtevant, 1955)

(Ruiz-Gomez et al., 2000)

wapl

(Kramers et al., 1991)

wds

(Kramers et al., 1991, Lin and Wolfner, 1989)

Zw10

(Kramers et al., 1991, Lin and Wolfner, 1989)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (0)

If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
In these cases, there will be no "Export to Hitlist" button to the left.

Related Comments

Phenotypic Data

In combination with other aberrations

Does not complement Df(1)w67k30.

(Ruiz-Gomez et al., 2000)

Covered by Dp(1;2)w-ec.

(Lefevre, 1968)

NOT in combination with other aberrations

Df(1)N-8/+ wings show notching of the distal wing margin.

(van de Hoef et al., 2013)

Df(1)N-8/+ adult females show wing defects that include thickening of the longitudinal vein 5.

Df(1)N-8/+ females ectopically expressing Hsap\ATXN1L^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^hh.PU rarely survive to adult stage (less than 10%) and the survivors display severe wing defects including a further thickening of the vein L5 compared to Df(1)N-8/+ controls.

(Tong et al., 2011)

Df(1)N-8 heterozygotes exhibit a dominant wing notching phenotype.

(Herz et al., 2010)

Heterozygotes show loss of wing margin and wing vein thickening.

(Herranz et al., 2006)

Flies bearing Df(1)N-8 are generally smaller than wild-type flies and have a transient, slightly brown, eye phenotype shortly after eclosion.

(Lloyd et al., 2002)

Df(1)N-8 flies exhibit a weak loss of wing margin.

(Stewart et al., 2001)

Shows dominant wing nicking which is enhanced by Psn^W11 and Psn^W6.

(Guo et al., 1999)

Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

(Coyne et al., 1998)

Heterozygotes of Df(1)N-8 or N^55e11 with Abl¹,Nrt^M54 or In(3L)std11 show defects in eye development leading to rough eyes with high penetrance.

(Giniger, 1998)

No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1.

(Halsell and Kiehart, 1998)

Shows no maternal enhancement of dpp^hr4.

(Nicholls and Gelbart, 1998)

Single cells from Df(1)N-8 embryos transplanted into the ventral neurogenic region of wild-type host embryos can give rise to both neural and epidermal cells.

(Stüttem and Campos-Ortega, 1997)

Dominantly causes tergite defects in less than 50% of run³ heterozygotes.

(Duffy et al., 1996)

Deficient embryos show an uninterpretable mutant midgut phenotype.

(Bilder and Scott, 1995)

Homozygous embryos are very abnormal compared to wild-type. Midgut primordia do not fuse, and Malpighian tubules branch.

(Harbecke and Lengyel, 1995)

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

Reveals antimorphic alleles of P{en1}wg^en11.

(Couso and Martinez Arias, 1994)

Hyperplasia of replicating sensory precursors: due to an increased number of ectodermal cells being recruited as sensory precursor cells. Extra precursor cells are recruited beyond the normal time window for neurogenesis in the PNS.

(Bodmer et al., 1993)

Heterozygous females exhibit reduced viability and fertility.

(Eeken and Sobels, 1990)

Stocks (1)

Kyoto

108911

Df(1)N-8/FM7c

Notes on Origin

Discoverer

Mohr, 7 Oct. 1918.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

DelNotch8

(Mackensen, 1935)

Df(1)N

(Herranz et al., 2006)

Df(1)N-8

(Ribot et al., 2022, van de Hoef et al., 2013, Casso et al., 2011, Tong et al., 2011, Ozdowski et al., 2009, Crest et al., 2007)

Df(1)N8

(Lloyd et al., 2002, Stewart et al., 2001, Johnston et al., 1999, Vervoort et al., 1997, Rhyu et al., 1994, Reuter et al., 1993, Gailey et al., 1991, Dushay et al., 1990, Lin and Wolfner, 1989, Thierry-Mieg, 1982)

Df(1)N⁸

(Leonardi et al., 2011, Quan et al., 2004, Ruiz-Gomez et al., 2000, Giniger, 1998, Rottgen et al., 1998, Cohen et al., 1997, Matsuzaki and Saigo, 1996, Bodmer et al., 1993, Dambly-Chaudiere and Leyns, 1992, Godt et al., 1991, Eeken and Sobels, 1990, Gateff and Mechler, 1989, Pastink et al., 1987, Wieschaus et al., 1984, Kramers et al., 1983, Sturtevant, 1955)

Df(1)Notch-8

(Herranz et al., 2006)

DfN-8

(van de Hoef et al., 2013)

DfN⁸

(Kramers et al., 1991)

N-8 Mohr

(Slizynska, 1938)

(Sanchez et al., 1994, Glass, 1933)

N⁸

(Christiansen et al., 2013, Tsubota et al., 2011, Herz et al., 2010, Stüttem and Campos-Ortega, 1997, Couso and Martinez Arias, 1994, Gateff, 1978, Shellenbarger and Mohler, 1975, Sturtevant, 1948)

N^N8

(Edgar et al., 1994)

Notch⁸

(Wu and Rao, 1999)

Name Synonyms

Deficiency (1) Notch

Secondary FlyBase IDs

FBal0029936
FBal0058507

References (86)

Report Sections

Open Close