FlyBase Aberration Report: Dmel\Df(1)N-81k1

General Information

Symbol

Df(1)N-81k1

Species

D. melanogaster

Name

Deficiency (1) Notch

FlyBase ID

FBab0000580

Feature type

chromosomal_deletion

Also Known As

Df(1)N^81k1, N^81K1, Df(1)N^81K

Computed Breakpoints include

3C5-3C6;3C9-3C10

Features within 3C5--3C10

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

X ray

(Grimwade et al., 1985)

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Grimwade et al., 1985)

Breakpoints

3C5-3C6;3C9-3C10

(Grimwade et al., 1985)

Causes alleles

Pde4^81k1

(Harbison et al., 2004, Martin et al., 2001, Qiu and Davis, 1993)

Carries alleles

Transposon Insertions

Formalized genetic data

bk1 << N << dnc << bk2

Genetic mapping information

Comments

The proximal deletion breakpoint breaks within the dnc transcription unit removing the transcription start sites 1 and 2.

(Qiu and Davis, 1993)

Breakpoint(s) molecularly mapped

(Chen et al., 1986)

-43.9 to -31.2 kb The zero coordinate used in locating the molecular lesions in the Notch deficiencies is the first Eco R1 site in Canton-S DNA proximal to the 3C7 breakpoint of In(1)N^76b8 (Kidd et al., 1983); it is 1.1 kb to the right of the zero coordinate used by Artavanis-Tsakonas et al., 1983

Comments on Cytology

All limits from polytene analysis (FBrf0042381)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

(Ruiz-Gomez et al., 2000, Zecchini et al., 1999, Spana and Doe, 1996, Green et al., 1993, Grimwade et al., 1985)

Pde4

(Qiu and Davis, 1993)

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

kirre

(Ruiz-Gomez et al., 2000)

rst

(Ruiz-Gomez et al., 2000)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (0)

If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
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Related Comments

Phenotypic Data

In combination with other aberrations

Complements Df(1)w67k30.

(Ruiz-Gomez et al., 2000)

The increased number of thoracic bristles seen in Df(1)N-81k1 heterozygotes is rescued almost to a wild-type number by Dp(1;2)51b.

(Brennan et al., 1997)

Lethal or semi-lethal when in combination with large deficiency alleles of E(spl).

(Shepard et al., 1989)

NOT in combination with other aberrations

Scutellar bristle number is not effected in Df(1)N-81k1/+ mutant adults.

(Babaoglan et al., 2009)

Mutant flies have margin defects at the distal wing tip, moderate thickening of wing vein 5 and deltas at the ends of the wing veins.

(Eid et al., 2008)

Heterozygotes show distal notching of the wing and thickening of the wing veins.

(Mahoney et al., 2006)

en and nub expressing multidendritic (md) neurons in the dorsal cluster are greatly over produced in Df(1)N-81k1 mutants.

(Brewster et al., 2001)

heterozygous flies have small notches at the distal portion of the wing. This is made more variable by the addition of neur^UAS.cLa, when driven by Scer\GAL4^VMQ

(Lai and Rubin, 2001)

The cuticle secreted by zygotic N mutants is crinkled. In the complete absence of zygotic or maternal N the cuticle is very disorganized and thin and often has a hole in the middle. The cells at the leading edge of the closing dorsal epidermis are elongated compared to the wild type, appearing stretched, as do more ventral cells. The midline which eventually forms does not fall along a straight line. For embryos derived from mutant germline clones the defects are more pronounced and dorsal closure fails. The epidermis consists of isolated patches. Df(1)N-81k1 suppresses the dorsal hole phenotypes caused by hep¹ and Df(2L)flp147E. Does not suppress dorsal-hole phenotype of pnr or zip mutants.

(Zecchini et al., 1999)

The RP2 motoneuron duplicated at the expense of the RP2sib. The aCC motoneuron is duplicated at the expense of the pCC interneuron. The Usib fates are duplicated at the expense of the U neurons. The dMP2 is duplicated at the expense of the vMP2. No change was observable in EL cell fate. This phenotype is the reciprocal of that shown for numb mutants. Mutant embryos show excess neuroblast formation characteristic of neurogenic mutants.

(Skeath and Doe, 1998)

Heterozygotes have a marked increase in the number of bristles on the notum.

(Brennan et al., 1997)

Dominantly enhances the phenotype of flies carrying Brd^mut123+GYmut in a wild-type background.

(Lai and Posakony, 1997)

Assymetric division of all the MP2 precursors formed is not altered, but the smaller vMP2 is transformed to the dMP2 fate. In numb¹ Df(1)N-81k1 double mutants all MP2 neurons develop as dMP2.

(Spana and Doe, 1996)

Embryos lacking Dl function, or maternal and zygotic N function, fail to develop principal midgut epithelial cells and no midgut epithelium develops.

(Tepass and Hartenstein, 1995)

Hemizygotes exhibit severe defects in the optic lobe and Bolwig's organ. Bolwig's organ has an increased number of cells that form an irregular cluster within the surrounding hyperplastic brain. The number of cells within the optic lobe also seem slightly increased. The morphology of the optic lobe cells has changed, cells are rounded and arranged in a solid cluster.

(Green et al., 1993)

Homozygotes die as embryos. Heterozygotes show notching of the wing.

(Grimwade et al., 1985)

Stocks (2)

Bloomington

3006

Df(1)N-81k1, Pde4^81k1/C(1)DX, y¹ w¹ f¹; SM1, Dp(1;2)51b/+

Kyoto

107522

Df(1)N-81k1, Pde4^81k1/C(1)DX, y¹ w¹ f¹; SM1, Dp(1;2)51b/+

Notes on Origin

Discoverer

Muskavitch.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

Df(1)81k

(Tian et al., 2004)

Df(1)N-81k1

Df(1)N^81K1

(Hartenstein et al., 1996, Hartenstein et al., 1994, Bate, 1993, Green et al., 1993, Hartenstein et al., 1992)

Df(1)N^81K

(Zhu et al., 2005, Tian et al., 2004, Koelzer and Klein, 2003)

Df(1)N^81k1

(Müller et al., 2013, Tsubota et al., 2011, Sanders et al., 2009, Eid et al., 2008, Tapanes-Castillo and Baylies, 2004, Ruiz-Gomez et al., 2000, Brennan et al., 1999, Brennan et al., 1999, Haag et al., 1999, Zecchini et al., 1999, Brennan et al., 1997)

Df(1)N^81k

(Kuan et al., 2009, Koelzer and Klein, 2006, Hayward et al., 2005, Qiu and Davis, 1993)

N^81K1

(Loza-Coll et al., 2014, Babaoglan et al., 2009, Brewster et al., 2001, Lai and Rubin, 2001, Lawrence et al., 2001, Barolo et al., 2000)

N^81k1

(Rebeiz et al., 2011, Mahoney et al., 2006, Kooh et al., 1993, Grimwade et al., 1985)

N^81k

(de Celis Ibeas and Bray, 2003)

l(1)N^81K1

(Spana and Doe, 1996)

Name Synonyms

Deficiency (1) Notch

Secondary FlyBase IDs

FBal0029935

References (44)

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