FlyBase Aberration Report: Dmel\Df(1)sc10-1

General Information

Symbol

Df(1)sc10-1

Species

D. melanogaster

Name

FlyBase ID

FBab0000928

Feature type

chromosomal_deletion

Also Known As

sc^10-1, In(1)sc^10.1, Df(1)sc^10-1, In(1)sc^10-1, sc^10.1

Computed Breakpoints include

1B1-1B2;1B2-1B3

Features within 1B1--1B3

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

1Lt - 1B1 | 1B14 - 1B3 | 1C1 - 1Rt

Progenitor

In(1)ac³

(Villares and Cabrera, 1987)

Mutagen

X ray

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Duffy et al., 1996)

Breakpoints

1B2;1B2

(Duffy et al., 1996)

Causes alleles

sc^10-1

(Amcheslavsky et al., 2014, Marcellini et al., 2005, Reeves and Posakony, 2005, Parks et al., 1997, Gomez-Skarmeta et al., 1995, van Doren et al., 1994, Gonzalez-Crespo and Levine, 1993, Jack and DeLotto, 1992, Lindsley and Zimm, 1992, Erickson and Cline, 1991, Jack et al., 1991, Held, 1990, Rodriguez et al., 1990, Villares and Cabrera, 1987)

Carries alleles

Transposon Insertions

Formalized genetic data

bk1 << ac << sc << bk2

Genetic mapping information

Comments

Maintains intact sc regulatory regions.

(Cubas et al., 1991)

Comments on Cytology

Left limit of break 1 from polytene analysis (citation unavailable) Right limit of break 1 from inclusion of ac (FBrf0042024) Left limit of break 2 from inclusion of sc (FBrf0042024) Right limit of break 2 from polytene analysis (citation unavailable)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

(Gupta and Rodrigues, 1997, Henrique et al., 1997, Jimenez and Ish-Horowicz, 1997, Leviten and Posakony, 1996, Bailey and Posakony, 1995, Gomez-Skarmeta et al., 1995, Ramaekers et al., 1995, Hinz et al., 1994, van Doren et al., 1994, Gonzalez-Crespo and Levine, 1993, Jack and DeLotto, 1992, Brown et al., 1991, Cubas et al., 1991, Duffy and Gergen, 1991, Jack et al., 1991, Martinez and Modolell, 1991, Campuzano et al., 1985)

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (0)

If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
In these cases, there will be no "Export to Hitlist" button to the left.

Related Comments

Phenotypic Data

In combination with other aberrations

NOT in combination with other aberrations

The notum lacks bristles and sensory organ precursor cells are absent in the wing disc in hemizygous males.

(Zarifi et al., 2012)

Adults do not develop bristles on the notum. Residual bristle formation is seen in the legs.

(Kaspar et al., 2008)

Hemizygous pharate adult males completely lack interommatidial bristles.

(Pepple et al., 2007)

Df(1)sc10-1 adults lack all external sensory organs in the notum.

(Pi et al., 2004)

Mutant adults have no bristles on the notum, but have a normal pattern of correctly attached flight muscles.

(Usui et al., 2004)

Df(1)sc10-1/Y flies have a bald notum.

(Giagtzoglou et al., 2003)

Df(1)sc10-1/Y flies are almost completely bald, lacking most mechanosensory organs. Most sensory organ precursor cells are missing in the wing discs of these animals.

(Lai, 2003)

Flies are almost devoid of micro- and macrochaetae.

(Nolo et al., 2000)

Flies hemizygous for Df(1)sc10-1 have bald nota, no SOPs are specified.

(Apidianakis et al., 1999)

Flies lack all sensory bristles. Scer\GAL4^455.2-mediated expression of Ggal\Cash4^UAS.cHa in the scutellar primordia induces ectopic scutellar bristles.

(Henrique et al., 1997)

Olfactory sensilla on the surface of the third antennal segment develop normally in Df(1)sc10-1 flies.

(Reddy et al., 1997)

Dominantly causes tergite defects in less than 50% of run³ heterozygotes.

(Duffy et al., 1996)

Glial cells of wing nerves are absent in adult wing and almost completely absent in the developing wing.

(Giangrande, 1995)

Homozygotes exhibit few bristles. Heat induced expression of P{CnASH} induces bristle formation on the thorax and distal segments of the legs.

(Grens et al., 1995)

Loss of all bristles on the notum.

(Hinz et al., 1994)

Hemizygotes fail to develop most of the adult external mechanosensory organs (FBrf0045760). Flies have low viability associated with severe uncoordination: unable to walk or stay upright.

(Kernan et al., 1994)

Viability is low although a few hemizygous males survive to adulthood. two P-type (P3 and P4) and one S-type bristle are present on the proboscis of surviving hemizygotes, all other bristles normally present on the proboscis are absent. Df(1)sc10-1 flies carrying sc^hs.PR can develop the complete labellum bristle pattern, when they are heat shocked at 0, 6 and 12 hours after puparium formation.

(Ray and Rodrigues, 1994)

Introduction of ac^T52.2 construct into an ac[-] sc[-] h[-] background causes ectopic bristles to appear along wing vein L5.

(van Doren et al., 1994)

The extreme sc phenotype may result from a combination of the truncated sc protein and the effect of the In(1)ac³ breakpoint on the transcription of ac.

(Villares and Cabrera, 1987)

male viability low The adults, which occasionally eclose, lack macro- and microchaetae, except those of the eye and wing margin. Homozygous cell clones in wing lack neurons except along anterior margin (Schubiger and Palka, 1985, Dev. Biol. 108: 399-410).

Stocks (4)

Bloomington

109

Df(1)sc10-1, sc^10-1/y¹ ac^Hw-1

6016

Df(1)sc10-1, sc^10-1 f^36a/FM6/Dp(1;Y)y²67g19.1

Kyoto

105739

Df(1)sc10-1, sc^10-1/y¹ ac^Hw-1

108554

Df(1)sc10-1, f^36a / FM6 / Dp(1;Y)y²67g19.1

Notes on Origin

Discoverer

Sturtevant, 1930.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

No deletion is detected in the cloned ac region. The parent In(1)ac³ breaks very close to the 5' of ac.

(Campuzano et al., 1985)

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

Df(1)sc10-1

(Akiba et al., 2024, Stagg et al., 2011, Kuzin et al., 2009)

Df(1)sc10-1, sc^10-1

(Jafar-Nejad et al., 2003)

Df(1)sc^10-1

(Li and Baker, 2018, Amcheslavsky et al., 2014, Giagtzoglou et al., 2003, Apidianakis et al., 1999, Henrique et al., 1997, Jimenez and Ish-Horowicz, 1997, Held, 1990, Villares and Cabrera, 1987)

Df(1)sc^10.1

(Kaspar et al., 2008)

In(1)ac³sc^10-1

(Usui et al., 2004)

In(1)ac³sc^10.1

(van de Bor et al., 2002)

In(1)sc^10-1

(Möller et al., 2005, Lai, 2003, Cadigan et al., 2002, del Alamo et al., 2002, Klein and Campos-Ortega, 1997, Jennings et al., 1995, Brown et al., 1991)

In(1)sc^10.1

(Escudero et al., 2005, Villa-Cuesta et al., 2003, Culi et al., 2001, Culi and Modolell, 1998, Modolell and Campuzano, 1998, Gomez-Skarmeta et al., 1995, Dominguez and Campuzano, 1993, Cubas and Modolell, 1992, Martinez and Modolell, 1991)

sc10.1

(Usui et al., 1995)

sc^10-1

(Miller et al., 2014, Zarifi et al., 2012, Johnson et al., 2011, Pepple et al., 2007, Pi et al., 2004, Giagtzoglou et al., 2003, Reddy et al., 1997, Leviten and Posakony, 1996, Ray and Rodrigues, 1994)

sc^10.1

(Grillenzoni et al., 1998, Klein and Campos-Ortega, 1997, Ramaekers et al., 1995)

Name Synonyms

Secondary FlyBase IDs

FBab0027885

References (74)

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