FlyBase Aberration Report: Dmel\Df(2L)M24F-B

General Information

Symbol

Df(2L)M24F-B

Species

D. melanogaster

Name

Deficiency (2L) Minute

FlyBase ID

FBab0001490

Feature type

chromosomal_deletion

Also Known As

Df(2L)M-zB, Df(2L)M-z^B, Df(2L)Mz^B, M(2)z^B

Computed Breakpoints include

24E1;25A2

Features within 24E1--25A2

Genomic Maps

JBrowse

Sequence coordinates

2L:4,228,561..4,323,781 (Df(2L)M24F-B:bk1)

(Cook, 2016.2.8)

2L:4,477,462..4,780,032 (Df(2L)M24F-B:bk2)

(Cook, 2016.2.8)

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

spontaneous

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Duffy et al., 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Stern and Ganetzky, 1992, Schupbach and Wieschaus, 1991, de Belle et al., 1989, Bryant et al., 1988, Szidonya and Reuter, 1988, Semeshin and Szidonya, 1985, Roy et al., 1984, Reuter and Szidonya, 1983)

Breakpoints

24E2-24F1;25A1-25A2

(Reuter and Szidonya, 1983)

24E1-24E2;24F6-24F7

(Duffy et al., 1996, Harbecke and Lengyel, 1995, de Belle et al., 1989, Semeshin and Szidonya, 1985)

24D8-24E1;24F7-25A1

(Bryant et al., 1988, Szidonya and Reuter, 1988)

24E2-24F1;24F6-24F7

(Pauli et al., 1995, Schupbach and Wieschaus, 1991, Schupbach and Wieschaus, 1989)

24E1;25A2

(Stern and Ganetzky, 1992)

24E2-24F1;25A1

(Roy et al., 1984)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

l(2)24Dc << bk1 << l(2)24EFg << l(2)24EFa << bk2 << slf

Genetic mapping information

Comments

The 2L:4228561..4323781 release 6 coordinates of the left breakpoint are estimates. The left extent corresponds to the right end of RpL40, which published results say is not deleted. The right extent corresponds to the right end of tutl, which published results say is deleted.

(Cook, 2016.2.8)

The 2L:4477462..4780032 release 6 coordinates of the right breakpoint are estimates. The left extent corresponds to the left end of dpy, which published results say is deleted. The right extent corresponds to the estimated position of the left end of band 25A5, because reported polytene cytologies indicate the breakpoint lies within the 25A1-4 quadruplet bands or to their left.

(Cook, 2016.2.8)

Comments on Cytology

Left limit of break 1 from polytene analysis (FBrf0042240) Right limit of break 1 from polytene analysis (FBrf0047784) Left limit of break 2 from polytene analysis (FBrf0056564) Right limit of break 2 from polytene analysis (FBrf0039034)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

dpy

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983, Curry, 1939)

dw-24E

(Kahsai and Cook, 2018, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983)

E(rst)D61

(Tanenbaum et al., 2000)

ine

(Stern and Ganetzky, 1992)

(Roy et al., 1984)

(Roy et al., 1984)

(Roy et al., 1984)

(Roy et al., 1984)

(Roy et al., 1984)

(Roy et al., 1984)

(Roy et al., 1984)

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)24Fc

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)cg

(Curry, 1939)

RpL27A

(Bryant et al., 1988, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Roy et al., 1984, Reuter and Szidonya, 1983, Curry, 1939)

Su(rst)D121

(Tanenbaum et al., 2000)

Su(var)2-8

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983)

Tps1

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

tutl

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

Partially deleted / disrupted

Molecular Data

Completely deleted

mRpL27

(Marygold et al., 2007)

RpL27A

(Marygold et al., 2007)

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

(Bryant et al., 1988, Reuter and Szidonya, 1983)

dpy

(Bryant et al., 1988)

(Bryant et al., 1988, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983)

for

(de Belle et al., 1989)

(Mahoney et al., 1991, Bryant et al., 1988, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983)

garz

(Reuter and Szidonya, 1983)

l(2)24Dc

(Bryant et al., 1988, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)24Dd

(Bryant et al., 1988, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)24De

(Bryant et al., 1988, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)25Ab

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)25Ba

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)25Bb

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)25Bc

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)25Bd

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)25Be

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)25Bf

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)25Bg

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)25Ca

(Bryant et al., 1988, Reuter and Szidonya, 1983)

M(2)24D

(Bryant et al., 1988, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983)

RpL37A

(Bryant et al., 1988, Reuter and Szidonya, 1983)

slf

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

Su(var)2-4

(Reuter and Szidonya, 1983)

Su(var)25F26B

(Reuter and Szidonya, 1983)

tkv

(Bryant et al., 1988, Reuter and Szidonya, 1983)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (72)

Related Comments

Phenotypic Data

In combination with other aberrations

Heterozygotes with Df(2L)M24F11 or Df(2L)tkv3 are lethal and with Df(2L)M24F11, Df(2L)ed1 or Df(2L)tkv2 are viable.

(Reuter and Szidonya, 1983)

Suppressed by In(2L)C158^LSco^rv11R.

(Ashburner et al., 1981)

Suppresses position-effect variegation in In(1)w^m4h

NOT in combination with other aberrations

Flies heterozygous for the deletion show a Minute bristle phenotype.

(Marygold et al., 2007)

The Df(2L)M24F-B chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion).

(Mason et al., 2004)

Acts as a dosage sensitive maternal modifier of run : causes tergite defects in greater than 50% of run³ heterozygotes.

(Duffy et al., 1996)

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

Large ventral cord cells.

(Smith et al., 1993)

Reduced viability and fertility.

(Szidonya and Reuter, 1988)

Homozygous lethal, shows a strong Minute phenotype. Chromosome has a suppressor effect on w variegation of In(1)w^m4h.

(Reuter and Szidonya, 1983)

M phenotype. Enhances bw^V1 (Duttagupta et al., 1984)

Stocks (2)

744

106059

Notes on Origin

Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

Df(2)MB

(Curry, 1939)

Df(2L)M-B

Df(2L)M-z^B

(Westphal and Reuter, 2002, de Belle et al., 1989, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Semeshin and Szidonya, 1985)

Df(2L)M-zB

(Duffy et al., 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Smith et al., 1993, Stern and Ganetzky, 1992, Mahoney et al., 1991, Schupbach and Wieschaus, 1989, Bryant et al., 1988)

Df(2L)M24-B^-

(van de Bor et al., 2002)

Df(2L)M24F-B

(Candia et al., 2023, Pan et al., 2022, Li et al., 2020, Sawyer et al., 2020, Lopez-Gonzalez et al., 2019, Kahsai and Cook, 2018, Mathew et al., 2009)

Df(2L)Mz^B

(Locke et al., 1988, Reuter and Szidonya, 1983)

DfM(2)-z^B

(Roy et al., 1984)

M(2)24F^B

M(2)z^B

(Agrawal et al., 1995, Agrawal et al., 1995)

M-z^B

Name Synonyms

Deficiency (2L) Minute

Df(2)Minute-Bridges

(Curry, 1939)

Secondary FlyBase IDs

FBab0022194
FBal0042663

References (41)

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