FlyBase Aberration Report: Dmel\Df(2L)Sco[rv18]

General Information

Symbol

Df(2L)Sco^rv18

Species

D. melanogaster

Name

Deficiency (2L) Scutoid

FlyBase ID

FBab0001549

Feature type

chromosomal_deletion

Also Known As

Df(2L)ScoR+18, Sco^R+18

Computed Breakpoints include

35B1--2;35E1--F1;35D2--7;[<35D]

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Tp(2;2)Sco

(Roote et al., 1996, Ashburner et al., 1983, Ashburner et al., 1980)

Mutagen

X ray

(Ashburner et al., 1980)

Class of aberration (relative to wild type)

chromosomal_deletion

Class of aberration (relative to progenitor)

chromosomal_deletion

(Ashburner et al., 1980)

Breakpoints

[];[]

(Ashburner et al., 1980)

35B1-35B2;35B2-35B4;35D1-35D2;35E2

(Ashraf et al., 1999)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

bk1 << noc << Adh << bk2 << mol << wor << bk3 << sna << BicC << bk4

Genetic mapping information

Comments

FBrf0091058 and FBrf0082309 differ in their conclusions about molecular mapping of the proximal breakpoint of Df(2L)Sco^rv18 with respect to the BicC transcription unit. Weight of evidence favours the FBrf0091058 interpretation (see Roote, 1999.1.18, personal communication).

Comments on Cytology

Cytology like Tp(2;2)Sco.

(Roote et al., 1996)

Stated to break in BicC transcription unit.

(Mahone et al., 1995)

Cytologically similar to Tp(2;2)Sco.

(Ashburner et al., 1983)

Cytologically invisible deletion.

(Ashburner et al., 1980)

Left limit of break 1 from non-inclusion of elA (FBrf0039455) Right limit of break 1 from inclusion of Adh (FBrf0034393) Left limit of break 2 from inclusion of BicC (FBrf0051973) Right limit of break 2 from non-inclusion of Ca-α1D (FBrf0051973) Left limit of break 3 from complementation mapping against wor (citation unavailable) Right limit of break 3 from polytene analysis (citation unavailable) Right limit of break 4 from polytene analysis (citation unavailable)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

Partially deleted / disrupted

noc

(Roote et al., 1996)

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

cact

(Ashburner et al., 1990)

Ca-α1D

(Ashburner et al., 1990)

chif

(Ashburner et al., 1990)

cni

(Ashburner et al., 1990)

crp

(Ashburner et al., 1990)

Cul3

(Ashburner et al., 1990, Ashburner et al., 1983)

Cyp303a1

(Ashburner et al., 1990)

dac

(Ashburner et al., 1990)

elA

(Ashburner et al., 1983)

esg

(Ashburner et al., 1990)

fzy

(Ashburner et al., 1990)

heix

(Ashburner et al., 1990)

l(2)36Aa

(Ashburner et al., 1990)

l(2)36Ab

(Ashburner et al., 1990)

l(2)36Ac

(Ashburner et al., 1990)

l(2)36Ad

(Ashburner et al., 1990)

mol

(Ashburner et al., 1983)

mRpL4

(Ashburner et al., 1990)

Pburs

(Ashburner et al., 1983)

plo

(Ashburner et al., 1990)

PolD3

(Ashburner et al., 1990, Ashburner et al., 1983)

stc

(Ashburner et al., 1990, Ashburner et al., 1983)

Su(H)

(Ashburner et al., 1990)

Syx5

(Ashburner et al., 1990)

TfIIS

(Ashburner et al., 1990)

Uxt

(Ashburner et al., 1990)

vas

(Ashburner et al., 1990)

wor

(Ashburner et al., 1990, Ashburner et al., 1983)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location

Related Comments

Unusual noc complementation data due to function of the two transcripts, nocA and nocB.

(Roote et al., 1996)

Phenotypic Data

In combination with other aberrations

37% of ISNb nerves show a bypass phenotype in Df(2L)RM5/Df(2L)Sco^rv18 embryos (20% of ISNb nerves are wild type). 68% of ISNd nerves show a bypass phenotype in Df(2L)RM5/Df(2L)Sco^rv18 embryos (29% of ISNd nerves are wild type).

(Pipes et al., 2001)

In Df(2L)Sco^rv18/Df(2L)RM5 transheterozygotes (beat-Ia^- BicC^-) the SNb fails to diverge from the ISN completely (full bypass) in 68% segments or partially (partial bypass) in 28% segments.

(Fambrough and Goodman, 1996)

NOT in combination with other aberrations

Stocks (0)

Notes on Origin

Discoverer

Ashburner.

Revertant

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Reported to delete Adhr in error; see FBrf0141768 for correction.

(Roote et al., 1996)

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

Df(2L)Sco18

Df(2L)Sco^R+18

(Ashburner et al., 1980)

Df(2L)Sco^R+

Df(2L)Sco^rv18

Df(2L)ScoR+18

(Pipes et al., 2001, Fambrough and Goodman, 1996, Mahone et al., 1995, Ashburner et al., 1990)

Df(2L)Scorv18

(Roote, 2002.1.15)

Sco-rv18

(Ashburner et al., 1999.10.12)

Sco^R+18

(Ashburner and Harrington, 1984, Ashburner et al., 1983)

Name Synonyms

Deficiency (2L) Scutoid

Secondary FlyBase IDs

References (14)

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